OPTIMISM BIAS [YES YOU TOO]

http://optimism.behaviouralfinance.net/
https://rpseawright.wordpress.com/2012/07/16/investors-10-most-common-behavioral-biases/

“…a well-established bias in which someone’s subjective confidence in their judgments is reliably greater than their objective accuracy. Indeed, we live in an overconfident, Lake Wobegon world (“where all the women are strong, all the men are good-looking, and all the children are above average”).  We are only correct about 80% of the time when we are “99% sure.” Fully 94% of college professors believe they have above-average teaching skills. 80% of drivers say that their driving skills are above average. While 70% of high school students claim to have above-average leadership skills, only 2% say they are below average, no doubt taught by above average math teachers. In a survey, 92% students said they were of good character and 79% said that their character was better than most people even though 27% of those same students admitted stealing from a store within the prior year and 60% said they had cheated on an exam. Venture capitalists are wildly overconfident in their estimations of how likely their potential ventures are either to succeed or fail. In a finding that pretty well sums things up, 85-90% of people think that the future will be more pleasant and less painful for them than for the average person.”

i-4dc90862f9a04bd0a1e5c6c8f3b78b79-mckinsey2-thumb-499x288-47119.png

INFLATED EARNINGS ESTIMATES
http://scienceblogs.com/cortex/2010/04/15/optimism-bias/
by Jonah Lehrer  /  April 15, 2010

“I’m pretty fascinated by this chart from the McKinsey Quarterly, which is a great demonstration of the optimism bias. The chart captures the earnings estimates of equity analysts for S&P 500 companies. The downward slope of these yellow lines is what happens when our hopeful projections meet dismal reality. Needless to say, these estimates come from highly paid professionals, with access to vast amounts of data. (They’re also making projections about the relatively near future.) Unfortunately, all that data is no match for a deep-seated bias, which leads us to accentuate the positive and downplay the prospect of potential losses. (This helps explain why earnings projections are even less accurate during economic downturns.) Interestingly, the only segment of the population that isn’t vulnerable to the optimism bias are people with major depressive disorder. Maybe Wall Street should think about hiring them.”

vs DEPRESSIVE REALISM
http://www.psychologytoday.com/articles/200802/magical-thinking

“We use ritual acts most often when there is little cost to them, when an outcome is uncertain or beyond our control, and when the stakes are high. People who truly trust in their rituals exhibit a phenomenon known as “illusion of control,” the belief that they have more influence over the world than they actually do. And it’s not a bad delusion to have—a sense of control encourages people to work harder than they might otherwise. In fact, a fully accurate assessment of your powers, a state known as “depressive realism,” haunts people with clinical depression, who in general show less magical thinking.”


Tali Sharot, a faculty member of the Department of Cognitive, Perceptual and Brain Sciences at University College London, is the author of “The Optimism Bias: A Tour of the Irrationally Positive Brain.”

MANAGING EXPECTATIONS
http://www.cnn.com/2012/06/24/opinion/sharot-optimism-bias/index.html
Why we fool ourselves into optimism
by Tali Sharot   /  Jun 24, 2012

“Close your eyes for a moment and imagine your life five years from now. What sort of scenarios pop into your mind? How do you see yourself standing professionally? What is the quality of your personal life and relationships? Though each of us may define “happiness” in different ways, it remains the case that we are inclined to see ourselves motoring happily toward professional success, fulfilling relationships, financial security and stable health. Unemployment, debt, Alzheimer’s, any number of other regrettably common misfortunes are rarely factored into our projections. According to most estimates, 80% of the population hold unrealistic, optimistic beliefs about their own future. However, ask people whether the economy is going in the right direction or how they feel about the future of their country, and you will hear: “absolutely not” and “going down the drain.” Collectively we are quite pessimistic about the direction of our nation or the ability of our leaders to improve education and reduce crime. But private optimism, about our personal future, remains incredibly resilient.

Surveys show that most people overestimate their prospects for personal achievement, expect their children to be extraordinarily gifted and hugely underestimate their likelihood of divorce and cancer. What always puzzled me was how we manage to maintain optimism in the face of reality. We experience failure and heartache, we read the newspaper — we know the economy is unstable, but still we remain optimistic about our own odds. As a neuroscientist I found this especially surprising, because according to all classic theories of learning when expectations are not met, we alter them. This should eventually lead to realism, not optimism.

By scanning the brains of people while they learned from positive and negative information about the future we uncovered a possible answer to this puzzle. Surprisingly, when people learn of what the future may hold, their brains faithfully encode desirable information that can enhance optimism, but fail at incorporating unexpectedly bad information. When we learn of Oprah Winfrey’s success story, our brain takes note and concludes that maybe, we too may become immensely rich one day. But when told the odds of divorce are almost 1 in 2 we take no notice. This means that warning signs such as those on cigarette packets may only have limited impact. “Yes, smoking kills — but mostly it kills the other guy.” But at the same when we hear the housing market is going up we think — “ohhhh the value of my house is going to double.”

In fact, economists have suggested that optimism was a root cause of the financial downfall of 2008. The optimism bias was not only blurring the vision of the private sector, but also of government officials, rating agencies and financial analysts who constantly expected the market to go up and up. The belief that we are relatively immune to future harms can also put us at physical risk. Take for example an e-mail I received from a California firefighter who read my book about the optimism bias. He says fatality investigations involving firefighters often include statements to the effect of “We didn’t think the fire was going to do that” even when all of the available information about risks was there to enable safe decisions.

The British government for one has decided to try to address these problems. As a first step, it has acknowledged that the optimism bias causes individuals to underestimate the cost and duration of projects. Specific guidelines of how to correct for the optimism bias in appraisals were published in the British government’s Green Book, which provides an overall methodology for economic assessment. Adjustments for the optimism bias have since been factored into the budget of many UK government projects, including most recently the 2012 London Olympics. Despite all these potential pitfalls, the science of optimism clearly indicates that, on balance, viewing the world through rose-tinted glasses is a good thing. We now know that underestimating the pain and difficulties the future undoubtedly holds lowers stress and anxiety, consequently enhancing physical and mental health.

Believing that a goal is within reach motivates us to act in a way that will help us attain it. This may, for instance, explain why optimists work longer hours and tend to earn more. Yes, the 2012 London Olympics budget had to be adjusted to account for over-optimistic prediction, but if the human spirit were not optimistic, would there be anyone around to participate in the actual Games? My guess is that the number of athletes who expect to win a medal at the Olympics significantly outnumbers the number of contestants who will mount the podium to be garlanded in due course. Most athletes subject themselves to years of intensive training because they can clearly envisage the end goal. At the end of the day, to make any kind of real progress we need to be able to imagine alternative realities — better ones, and believe them to be possible.”

BIAS REMOVAL
http://theoptimismbias.blogspot.com/p/scientific-papers.html
http://www.time.com/time/health/article/0,8599,2074067,00.html
http://www.brainpickings.org/index.php/2012/12/12/science-of-optimism-sharot/
http://www.the-scientist.com/?articles.view/articleNo/32642/title/Removing-the-Optimism-Bias-/
http://www.scientificamerican.com/article.cfm?id=unflagging-optimism

“Most of us hold unrealistically optimistic views of the future, research shows, downplaying the likelihood that we will have bad experiences. Now a study inNature Neuroscience last October has found clues to the brain’s predilection for the positive, identifying regions that may fuel this “optimism bias” by preferentially responding to rosier information. Tali Sharot, a University College London neurology researcher, and her colleagues asked 19 individuals between the ages of 19 and 27 to estimate their odds of experiencing 80 unfavorable events, such as contracting various diseases or being the victim of a crime. Participants were then told the actual average probability of each before repeating the exercise.

The participants revised most of their estimates the second time around, but 79 percent of those tested paid much more attention when their actual risk was lower than what they had initially guessed. After getting the good news, these subjects rated their risk for these events as significantly lower than they did earlier. In contrast, when they had underestimated their odds of meeting with a particular misfortune, they made less drastic revisions to their guess or none at all—clinging to their earlier belief that they would probably avoid the bad luck. Using functional MRI, the resear­chers found areas in the prefrontal cortex, where conscious reasoning takes place, that were active when participants received infor­mation that was better than anticipated. The greater the difference between the subjects’ initial guess of their risk and the true probability, the more activity appeared in these regions, hinting that they contribute to positive error correction.

Activity in another part of the brain, the right inferior frontal gyrus, changed in response to discouraging information. There, however, activity did not correspond as closely with the magnitude of error in the participants’ initial risk estimates, matching the poorer correction later. That incon­sistent neural response was ob­served most clearly or most often in individuals who scored higher on standard tests for optimism as a personality trait. This finding jibes with past studies that observed an optimism bias in about 80 percent of the population. Its absence can signal anxiety or depression. Yet being overly optimistic has consequences, too, Sharot says, preventing us from taking some precautions to avoid harm or misfortune. Realizing the brain’s partiality may be half the battle. “If you are aware of the optimism bias, you can commit to actions or rules that will help protect you,” Sharot notes.” 

LEARNING CURVE
http://blogs.wsj.com/totalreturn/2011/10/28/this-is-your-brain-on-gains/
by Jason Zweig  /  October 28, 2011

“Why is it so hard for investors to learn from their mistakes? One reason, according to new research by a team of neuroscientists in London and Berlin: We learn more when results are better than expected than when they are worse than expected. In effect, your brain perceives the world through rose-colored glasses. In a recent experiment, people were asked to estimate the odds of suffering 80 different bad outcomes—being robbed, getting cancer, developing Alzheimer’s disease and so forth. Then they were shown the actual probability of those events. Finally, in a later session, they were asked to recall the probabilities of each of the 80 events. It turned out that people’s final estimates of probabilities were much more accurate when their first round of guesses had been too pessimistic. Whenever reality had turned out to be better than they had anticipated, people’s future forecasts became significantly more accurate.

In short, humans don’t learn equally well from upside and downside mistakes. Because we have what researcher Tali Sharot calls an “optimism bias,” we pay more attention when the future turns out to be better than we expected. If you bought Apple at $60 a share thinking maybe it would double, you’ve probably spent a fair amount of time wondering why you underestimated its potential and trying to apply those lessons to find other great stocks. On the other hand, if you bought Netflix at $200 a share, never dreaming it would go down by more than half, you’re probably not doing much self-reflection at all; you’re looking for somebody to blame.

At a recent meeting of more than 100 financial advisers and wealthy investors, I asked how many thought they added value to their portfolios with their selling decisions. Almost all the hands went up. I then asked how many tracked the returns of the stocks they sold after they sold them. Two-thirds of the hands went down. But, of course, there’s no way to know whether it was a good idea to sell one stock and replace it with another unless you systematically track how both of them did after the trade. The lesson: Investors must force themselves to study their mistakes, or they will never learn from them.  Otherwise your automatically optimistic brain will keep you from confronting the truth.”

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GUT CHECK

‘INTESTINAL FLORA’


This bacterium also is able to use so-called “nondigestible” plant polymers or host-derived glycoproteins and glycoconjugates; it is thought that Bifidobacterium’s ability to compete with other gastrointestinal bacteria and occupy a large percentage in the bacterial flora of the gastrointestinal region might be partly due to the large variety of molecules that it is able to use for energy.

GUT ECOLOGY TYPES
http://www.nytimes.com/2012/06/19/science/studies-of-human-microbiome-yield-new-insights.html
http://www.nytimes.com/2011/04/21/science/21gut.html
Bacterial Ecosystems Divide People Into 3 Groups, Scientists Say
by Carl Zimmer  /  April 20, 2011

In the early 1900s, scientists discovered that each person belonged to one of four blood types. Now they have discovered a new way to classify humanity: by bacteria. Each human being is host to thousands of different species of microbes. Yet a group of scientists now report just three distinct ecosystems in the guts of people they have studied.

The researchers, led by Peer Bork of the European Molecular Biology Laboratory in Heidelberg, Germany, found no link between what they called enterotypes and the ethnic background of the European, American and Japanese subjects they studied. Nor could they find a connection to sex, weight, health or age. They are now exploring other explanations. One possibility is that the guts, or intestines, of infants are randomly colonized by different pioneering species of microbes. The microbes alter the gut so that only certain species can follow them.

Whatever the cause of the different enterotypes, they may end up having discrete effects on people’s health. Gut microbes aid in food digestion and synthesize vitamins, using enzymes our own cells cannot make. Dr. Bork and his colleagues have found that each of the types makes a unique balance of these enzymes. Enterotype 1 produces more enzymes for making vitamin B7 (also known as biotin), for example, and Enterotype 2 more enzymes for vitamin B1 (thiamine). The discovery of the blood types A, B, AB and O had a major effect on how doctors practice medicine. They could limit the chances that a patient’s body would reject a blood transfusion by making sure the donated blood was of a matching type. The discovery of enterotypes could someday lead to medical applications of its own, but they would be far down the road. “Some things are pretty obvious already,” Dr. Bork said. Doctors might be able to tailor diets or drug prescriptions to suit people’s enterotypes, for example. Or, he speculated, doctors might be able to use enterotypes to find alternatives to antibiotics, which are becoming increasingly ineffective. Instead of trying to wipe out disease-causing bacteria that have disrupted the ecological balance of the gut, they could try to provide reinforcements for the good bacteria. “You’d try to restore the type you had before,” he said. Dr. Bork notes that more testing is necessary. Researchers will need to search for enterotypes in people from African, Chinese and other ethnic origins. He also notes that so far, all the subjects come from industrial nations, and thus eat similar foods. “This is a shortcoming,” he said. “We don’t have remote villages.”

The discovery of enterotypes follows on years of work mapping the diversity of microbes in the human body — the human microbiome, as it is known. The difficulty of the task has been staggering. Each person shelters about 100 trillion microbes. (For comparison, the human body is made up of only around 10 trillion cells.) But scientists cannot rear a vast majority of these bacteria in their labs to identify them and learn their characteristics. As genetics developed, scientists learned how to study the microbiome by analyzing its DNA. Scientists extracted DNA fragments from people’s skin, saliva and stool. They learned how to recognize and discard human DNA, so that they were left with genes from the microbiome. They searched through the remaining DNA for all the variants of a specific gene and compared them with known species. In some cases, the variants proved to be from familiar bacteria, like E. coli. In other cases, the gene belonged to a species new to science.

These studies offered glimpses of a diversity akin to a rain forest’s. Different regions of the body were home to different combinations of species. From one person to another, scientists found more tremendous variety. Many of the species that lived in one person’s mouth, for example, were missing from another’s. Scientists wondered if deeper studies would reveal a unity to human microbiomes. Over the past few years, researchers have identified the genomes — the complete catalog of genes — of hundreds of microbe species that live in humans. Now they can compare any gene they find with these reference genomes. They can identify the gene’s function, and identify which genus of bacteria the microbe belongs to. And by tallying all the genes they find, the scientists can estimate how abundant each type of bacteria is.

In the recent work, Dr. Bork and his team carried out an analysis of the gut microbes in 22 people from Denmark, France, Italy and Spain. Some of their subjects were healthy, while others were obese or suffered from intestinal disorders like Crohn’s disease. Dr. Bork and his colleagues searched for fragments of DNA corresponding to the genomes of 1,511 different species of bacteria. The researchers combined their results with previous studies of 13 Japanese individuals and 4 Americans. The scientists then searched for patterns. “We didn’t have any hypothesis,” Dr. Bork said. “Anything that came out would be new.” Still, Dr. Bork was startled by the result of the study: all the microbiomes fell neatly into three distinct groups. And, as Dr. Bork and his colleagues reported on Wednesday in the journal Nature, each of the three enterotypes was composed of a different balance of species. People with type 1, for example, had high levels of bacteria called Bacteroides. In type 2, on the other hand, Bacteroides were relatively rare, while the genus Prevotella was unusually common. “You can cut the data in lots of different ways, and you still get these three clusters,” Dr. Bork said. Dr. Bork and his colleagues found confirmation of the three enterotypes when they turned to other microbiome surveys, and the groups continue to hold up now that they have expanded their own study to 400 people.

The geographic distribution and bacterial diversity of the included samples. (Credit: Tito et al. Insights from Characterizing Extinct Human Gut Microbiomes. PLoS ONE, 2012; 7 (12): e51146 DOI: 10.1371/journal.pone.0051146)

BEFORE ANTIBIOTICS
http://www.ou.edu/content/web/news_events/articles/news_2012/bacteriastudy.html
http://www.sciencedaily.com/releases/2009/01/090105175354.htm
http://www.sciencedaily.com/releases/2012/12/121213132546.htm
Bacterial Ecology That Lives On Humans Has Changed in Last 100 Years  /  Dec. 13, 2012

A University of Oklahoma-led study has demonstrated that ancient DNA can be used to understand ancient human microbiomes. The microbiomes from ancient people have broad reaching implications for understanding recent changes to human health, such as what good bacteria might have been lost as a result of our current abundant use of antibiotics and aseptic practices. Cecil M. Lewis Jr., professor of anthropology in the OU College of Arts and Sciences and director of the OU Molecular Anthropology Laboratory, and Raul Tito, OU Research Associate, led the research study that analyzed microbiome data from ancient human fecal samples collected from three different archaeological sites in the Americas, each dating to over 1000 years ago. In addition, the team provided a new analysis of published data from two samples that reflect rare and extraordinary preservation: Otzi the Iceman and a soldier frozen for 93 years on a glacier.

“The results support the hypothesis that ancient human gut microbiomes are more similar to those of non-human primates and rural non-western communities than to those of people living a modern lifestyle in the United States,” says Lewis. “From these data, the team concluded that the last 100 years has been a time of major change to the human gut microbiome in cosmopolitan areas. Dietary changes, as well as the widespread adoption of various aseptic and antibiotic practices have largely benefited modern humans, but many studies suggest there has been a cost, such as a recent increase in autoimmune related risks and other health states,” states Lewis. ”We wish to reveal how this co-evolutionary relationship between humans and bacteria has changed, while providing the foundation for interventions to reconstruct what has been lost. One way to do this is to study remote communities and non-human primates. An alternative path is to look at ancient samples and see what they tell us,” Lewis says. ”An argument can be made that remote traditional communities are not truly removed from modern human ecologies. They may receive milk or other food sources from the government, which could alter the microbial ecology of the community. Our evolutionary cousins, non-human primates are important to consider. However, the human-chimp common ancestor was over six million years ago, which is a lot of time for microbiomes to evolve distinct, human signatures.”

Retrieving ancient human microbiome data is complementary to these studies. However, studying ancient microbiomes is not without problems. Assuming DNA preserves, there is also a problem with contamination and modification of ancient samples, both from the soil deposition, and from other sources, including the laboratory itself. ”In addition to laboratory controls in our study, we use an exciting new quantitative approach called source tracking developed by Dan Knights from Rob Knight’s Laboratory at the University of Colorado in Boulder, which can estimate how much of the ancient microbiome data is consistent with the human gut, rather than other sources, such as soil,” explains Lewis. ”We discovered that certain samples have excellent gut microbiome signatures, opening the door for deeper analyses of the ancient human gut, including a better understanding of the ancient humans themselves, such as learning more about their disease burdens, but also learning more about what has changed in our gut today.”

MICROBIOMES
http://blogs.discovermagazine.com/notrocketscience/2012/05/09/three-nations-divided-by-common-gut-bacteria/
Three nations divided by common gut bacteria
by Ed Yong  /  May 9, 2012

A child from the village of Chamba in rural Malawi has very little in common with one living in the city of Philadelphia in the USA. They eat different food, speak different languages, and enjoy different lifestyles. But they are both united by the fact that they are vessels for teeming hordes of bacteria. These children, like all of us, are home to trillions of bacteria and other microbes. These passengers outnumber our own cells by ten to one, and their genes outnumber ours by a hundred to one. Collectively, they’re known as the microbiome, and they are as much a part of us as any one of our own organs. Theybreak down our foodsafeguard our health, and affect our minds. And they have become intensely fashionable.

Microbiome research is booming, fuelled by the realisation that these microbes might provide a deeper understanding of our bodies, and new ways of diagnosing or treating diseases. But,with some exceptions, most microbiome studies have focused on wealthy populations from Europe, North America and Japan. There’s a risk that the bacteria of people from the developing world will be ignored.

Tanya Yatsunenko has led one of the largest efforts yet to remedy that problem. Working with Rob Knight and Jeffrey Gordon, she amassed an international collection of faecal samples and studied the gut microbes of people three diverse populations: 100 Guahibo people from the Venezuelan Amazon; 115 people from four Malawian villages; and 316 people from three American cities. The recruits ranged from newborn babies to 70-year-old adults. “The paper represents a heroic effort,” says David Relman, who studies the microbiome at Stanford University. “It’s the most definitive cross-culture and multi-age assessment of the human microbiome to date.” First, the similarities. Yatsunenko found that in all three countries, newborn babies have the greatest variety of gut bacteria, both in the species and the genes they carry. As they grow up, especially in their first three years, their microbiomes diversify, while the differences between individuals shrink. This means that adults end up with more diverse gut communities compared to babies, but more similar ones compared to each other. No one really knows why this happens, although studies are afoot to find out. But for now, it tells us that the microbiome matures along a “consistent developmental program”, according to Knight.

The guts of babies are dominated by Bifidobacterium – the group that’s commonly found in probiotic foods. They’re also loaded with genes for producing folate, an essential B-vitamin that’s involved in creating and repairing DNA. These folate-making genes decline as babies grow up, and get more of the vitamin from their diets. At the same time, the genes for making other vitamins, like B1, B7 and especially B12, become more common.  “This similarity across cultures in building up the gut microbiome in childhood has been touched on before but it’s much more convincing here,” says Peer Bork, from theEuropean Molecular Biology Laboratory. As adults, microbiomes fell along a spectrum, whose extremes are characterised by two groups: Bacteroides or Prevotella. There’s a trade-off between them, so people either have aBacteroides-rich gut or a Prevotella-rich one. Note that these aren’t necessarily the most common microbes around; they’re just the most distinctive.

Now, the differences. The genetic variation within human populations is greater than the variation between them. The same is true of our microbiomes. That being said, Yatsunenkodid find distinct differences between the microbes of all three countries, and especially between the Americans and the other two. These differences seemed to be largely driven by different diets. For example, Malawian and Venezuelan babies had more gut genes for making vitamin B2 compared to American ones. The vitamin is found in breast milk, meat and dairy products, and it may be that American babies (whose mothers eat more dairy and meat) get more vitamin B2 than those from the other countries. The Malawian and Venezuelan babies also had more genes for harvesting the readily available sugars in breast milk, although these dwindle away as they get older. As their diet shifts towards high-fibre foods like corn and cassava, their gut bacteria become loaded with genes for breaking down more complex sugars and starches. For American babies, the opposite is true. With a lifelong diet of refined sugars ahead of them, the genes for harvesting these nutrients become moreabundant as they get older. And since they eat high-protein diets, their gut bacteria become rife with genes for breaking down amino acids.

Yatsunenko also found differences at the level of individual species. For example, Malawian and Venezuelan gut communities contained more Prevotella microbes. This fits with the results from previous studies, which showed thatpeople who eat a high-fat or high-protein diet (including European children) tend towards the Bacteroides end of the spectrum, while those who eat lots of carbohydrates (includingvillagers from Burkina Faso) lie at Prevotella end. These differences could well be due to other aspects of the volunteers’ lifestyles, but it’s telling that they mirror the differences between meat-eating and plant-eating mammals. Just like the Americans, carnivore microbiomes are also packed with protein-busting genes, while herbivore microbiomes are rich in the starch-breaking genes that are common in Malawaians and Venezuelans guts.

Results like these are invaluable. At a time when we’re thinking of manipulating the microbiome to improve our health, it’s vital that we understand how our microbial partners are affected by our age, diet and culture. We need to expand our knowledge of the microbiome beyond the confines of the Western world. Yatsunenko’s study is certainly a step in the right direction, but even she describes it as a “demonstration project”. We need many more such studies, with more volunteers from all parts of the world. There’s a certain urgency to this work. As many parts of the world shift towards a western lifestyle, there’s a risk that we might lose important reservoirs of bacterial diversity. The microbiomes of the world are becoming increasingly gentrified, and we need to study them while we still can. Early studies gave us the opening lines to the microbiome story, and this study fleshes out a few more themes and characters. There are still many chapters left to write.

Reference: Yatsunenko, Rey, Manary, Trehan, Dominguez-Bellos, Contreras, Magris, Hidalgo, Baldassanos, Anokhin, Heath, Warner, Reeder, Kuczynski, Caproraso, Lozupone, Lauber, Clemente, Knights, Knight & Gordon. 2012. Human gut microbiome viewed across age and geography. Nature http://dx.doi.org/10.1038/nature11053

An extra word on splitters and lumpers: Canny readers might notice that I talk about a spectrum of microbiomes dominated by Prevotella and Bacteroides. This differs from the conclusions of a study I covered in 2011, which suggested thatgut microbiomes can be classified into three discrete ‘enterotypes’, characterised by BacteroidesPrevotella andRuminococcus (more recently replaced byMethanobrevibacter). So, one continuous spectrum, or three distinct clusters? News of this debate emerged at a Paris conference in March, and I covered the story for Nature. Head over there for the full details. In the meantime, Peer Bork, who led the original enterotype study, mentioned to me that the technique that Yatsunenko used might miss out some rarer microbes such as Methanobrevibacter. As such, the third enterotype might be invisible. He has a study in the pipeline that bolsters the enterotype concept. This debate, it seems, will continue for a while.

BREAST MILK ECOLOGY
http://ajcn.nutrition.org/content/96/3/544
http://www.sciencedaily.com/releases/2013/01/130104083103.htm
Breast Milk Contains More Than 700 Species of Bacteria, Spanish Researchers Find / Jan. 4, 2013

Spanish researchers have traced the bacterial microbiota map in breast milk, which is often the main source of nourishment for newborns. The study has revealed a larger microbial diversity than originally thought: more than 700 species. The breast milk received from the mother is one of the factors determining how the bacterial flora will develop in the newborn baby. However, the composition and the biological role of these bacteria in infants remain unknown. A group of Spanish scientists have now used a technique based on massive DNA sequencing to identify the set of bacteria contained within breast milk called microbiome. Thanks to their study, pre- and postnatal variables influencing the micriobial richness of milk can now be determined. Colostrum is the first secretion of the mammary glands after giving birth. In some of the samples taken of this liquid, more than 700 species of these microorganisms were found, which is more than originally expected by experts. The results have been published in the American Journal of Clinical Nutrition. “This is one of the first studies to document such diversity using the pyrosequencing technique (a large scale DNA sequencing determination technique) on colostrum samples on the one hand, and breast milk on the other, the latter being collected after one and six months of breastfeeding,” explain the coauthors, María Carmen Collado, researcher at the Institute of Agrochemistry and Food Technology (IATA-CSIC) and Alex Mira, researcher at the Higher Public Health Research Centre (CSISP-GVA). The most common bacterial genera in the colostrum samples were Weissella, Leuconostoc, Staphylococcus, Streptococcus and Lactococcus. In the fluid developed between the first and sixth month of breastfeeding, bacteria typical of the oral cavity were observed, such as Veillonella, Leptotrichia and Prevotella. “We are not yet able to determine if these bacteria colonise the mouth of the baby or whether oral bacteria of the breast-fed baby enter the breast milk and thus change its composition,” outline the authors.

The heavier the mother, the fewer the bacteria
The study also reveals that the milk of overweight mothers or those who put on more weight than recommended during pregnancy contains a lesser diversity of species. The type of labour also affects the microbiome within the breast milk: that of mothers who underwent a planned caesarean is different and not as rich in microorganisms as that of mothers who had a vaginal birth. However, when the caesarean is unplanned (intrapartum), milk composition is very similar to that of mothers who have a vaginal birth. These results suggest that the hormonal state of the mother at the time of labour also plays a role: “The lack of signals of physiological stress, as well as hormonal signals specific to labour, could influence the microbial composition and diversity of breast milk,” state the authors.

Help for the food industry
Given that the bacteria present in breast milk constitute one of initial instances of contact with microorganisms that colonise the infant’s digestive system, the researchers are now working to determine if their role is metabolic (it helps the breast-fed baby to digest the milk) or immune (it helps to distinguish beneficial or foreign organisms). For the authors, the results have opened up new doors for the design of child nutrition strategies that improve health. “If the breast milk bacteria discovered in this study were important for the development of the immune system, its addition to infant formula could decrease the risk of allergies, asthma and autoimmune diseases,” conclude the authors.

This microbe is making you fat

MICROBE SPURS OBESITY
http://www.news-medical.net/news/20121219/Changes-in-cholesterol-metabolism-induced-by-diet-can-alter-the-gut-flora.aspx
http://www.chinadailyapac.com/article/chinese-research-proves-bacteria-blame-causing-obesity
http://io9.com/5970677/this-microbe-is-making-you-fat
This microbe is making you fat
by Annalee Newitz  /  Dec 21, 2012

The difference between an obese person and a thinner one may not be just diet. Certain microbes that live naturally in our guts may contribute a great deal to whether we become obese and develop obesity-related illnesses such as diabetes. A study published this week demonstrated that a person suffering from obesity was also suffering from extremely elevated levels of a group of gut bacteria called Enterobacter. In fact, Enterobacter comprised 35% of the bacteria in this person’s colon.

When Enterobacter die or suffer damage to their cell walls, they release endotoxins, substances that often provoke a strong immune response in other cells. And these immune responses can cause inflammation that tips over into hypertension, diabetes, hyperglycemia, and even colitis. Once the experimental subject had lost over 50 kg, the amount of Enterobacter in their gut became so small as to be undetectable — and they stopped suffering the effects of hypertension and hyperglycemia. The researchers attribute this transformation to a shift in diet. A high fat diet leads to a population explosion in these bacteria, who release a lot of endotoxins into the body. In their study, the researchers discovered that mice with Enterobacter in their systems rapidly became obese when fed on a high-fat diet; mice with Enterobacter who ate regular chow did not. What this suggests is that Enterobacter could promote obesity in people with a high fat diet, and also might make their obesity far more deadly. Previously, other research teams have found that high fat diets seem to interact with other gut microbes to cause inflammatory diseases like colitis.

Every human contains millions of microbes throughout our bodies, most of which contribute significantly to keeping us healthy. All those microbes put together are called a microbiome — it’s sort of like an ecosystem of microbes. We each have a slightly different microbiome. Scientists have identified several distinct types of human microbiome, and there may be many more. People unlucky enough to have Enterobacter in their microbiomes may be more susceptible to obesity-related diseases, and indeed to obesity itself.


Iguana. Green iguanas establish their intestinal microbiomes by feeding first on soil and later on the feces of adult iguanas. (Credit: © Sebastian Duda / Fotolia)

PARASITES AFFECT HOST BEHAVIOR
http://www.sciencedaily.com/releases/2012/10/121011162152.htm
Animals’ Microbial Communities Linked to Their Behavior / Oct. 11, 2012

New research is revealing surprising connections between animal microbiomes — the communities of microbes that live inside animals’ bodies — and animal behavior, according to a paper by University of Georgia ecologist Vanessa O. Ezenwa and her colleagues. The article, just published in the Perspectives section of the journal Science, reviews recent developments in this emerging research area and offers questions for future investigation. The paper grew out of a National Science Foundation-sponsored workshop on new ways to approach the study of animal behavior. Ezenwa, an associate professor in the UGA Odum School of Ecology and College of Veterinary Medicine department of infectious diseases, and her coauthors were interested in the relationship between animal behavior and beneficial microbes. Most research on the interactions between microbes and their animal hosts has focused on pathogens, Ezenwa said. Less is known about beneficial microbes or animal microbiomes, but several recent studies have begun to explore these connections. ”We know that animal behavior plays a critical role in establishing microbiomes,” she said. “Once they’re established, the microbiomes then influence animal behavior in lots of ways that have far-reaching consequences. That’s what we were trying to highlight in this article.”

Bumble bees, for example, obtain the microbes they need through social contact with nest mates, including consuming their nest mates’ feces-a not uncommon method for animals to acquire microbes. Green iguanas establish their intestinal microbiomes by feeding first on soil and later on the feces of adult iguanas. ”There are a lot of behaviors that animals might have that allow them to get the different microbes they need at different points of their lives,” Ezenwa said. Microbes, in their turn, influence a wide range of animal behaviors, including feeding, mating and predator-prey interactions. One recent study found that fruit flies prefer to mate with others that have microbiomes most similar to their own. Another found that African malaria mosquitoes were less attracted to humans who had a greater diversity of microbes on their skin, possibly because certain microbes produce chemicals that repel these mosquitoes. Other studies have focused on understanding the mechanisms by which microbes influence behavior. ”Recent experiments have been able to assess the molecules that are involved in communication between microbes in the gut and the brain of mice, showing that microbes are associated with shifts in things like depression and anxiety in these mice,” she said. “There are huge implications in the role these microbes play in regulating neural function.” Ezenwa’s own work involves investigating how social behavior and interactions between organisms might increase their likelihood of acquiring parasites and pathogens. She is starting a new project examining animal behavior and microbiomes in relation to infectious disease. ”As in the example of the bumble bees, behavior might control the microbes an animal acquires, and those microbes might then influence the animal’s vulnerability to pathogens,” she said.

CROWD-FUNDED RESEARCH
https://www.scientificamerican.com/article.cfm?id=microbiome-survey
http://www.sciencedaily.com/releases/2012/06/120613133249.htm
http://singularityhub.com/2012/12/28/biotech-startup-ubiome-aims-to-sequence-the-bacteria-that-call-our-bodies-home/
Biotech Startup uBiome Aims to Sequence the Bacteria that Call Our Bodies Home
by David J. Hill  /  12/28/12

When you look at your body in the mirror, most of what you consider to be “you” actually isn’t you, at least not in a biological sense. That’s because there are approximately 10 bacterial cells for every single human cell in the body. Startling, yes, but that’s just the tip of the iceberg. Each human body may contain hundreds of thousands of species of bacteria, providing over 350 times the number of genes that is within our own genome,according to an article from Scientific American published last June. As we consider the issues of health and longevity, the big questions that naturally arise are, what exactly are all these bacteria and what relationship does each have with human physiology? That’s not exactly an easy problem, but fortunately efforts to more rigorously study the bacteria in the body, also known as the microbiome, are underway in research laboratories around the world. Now, a startup called uBiome has recently launched a project on Indiegogo to map human microbiomes through crowdsourced funding and open up sequencing to a much larger pool of people. With a minimum pledge of $79 to the project, users will receive a kit to obtain samples from their body in order to have their microbiome sequenced. Now, the kit comes with cotton swabs to remove samples of bacterial flora from the mouth, ear, nose, genitalia, or GI tract. Users submit the kit and complete a survey about themselves, and once sequenced, uBiome provides the results, an analysis of what the data mean, charts that compare the user’s microbiome to others in the database, and finally the latest research about the bacteria identified. In the press release, cofounder Zachary Apte said, “We have two aims with uBiome. First, we want to make the science and the technology available to everyone. Now anyone can have their microbiome sequenced. Second, we want to curate the world’s largest microbiome dataset. Citizen science is the answer.”

With an initial target of 1,000 users, the project so far has nearly 600 backers who have donated enough to receive at least one GI microbiome kit. To receive kits that will enable sequencing at all five different sites, a pledge of $335 is required, and few have opted for the level of mapping. Though dependent on large numbers of participants to be meaningful, the kind of gross comparative analysis that uBiome provides can be qualitatively insightful. For instance, users could see how their microbioome compares to those in the same geographical region. As the website points out, people who suffer from diabetes or irritable bowel disorder can see how their microflora compare to others with the same conditions. Or perhaps those who are on restricted diets, such as low carb or gluten free, could glean insight into how successful they are with their food choices based on the kinds of bacteria in their GI tracts. Finally, there’s also the issue of excesses, like alcohol or coffee, that could show users how their choices are impacting the microecosystems within their bodies. Analysis of microbiome data could give users insight about what’s going on inside their bodies that cannot be measured by current medical practices. Whether any of this information will be able to be tied to specific research that suggests a lifestyle change is in order remains to be seen. But as the human microbiome continues to be researched, more discoveries are bound to make this personal data meaningful. “We believe the biological information era is going to follow the same trend that the internet did,” said uBiome cofounder Jessica Richman in the press release. “When citizens became empowered to explore the internet via search engines like Google, usage skyrocketed. With uBiome, people can explore their personal metagenome from home.” It’s a bit overwhelming to realize just how little is understood still about the human body. In fact, it was only a few years ago that doctors at Duke University Medical School proposed a beneficial function of the appendix, long thought of as a vestigial organ left over from evolutionary development. Their theory is that the appendix replenishes good bacteria into the gut, which is vital after things like diarrhea effectively slough the top layer of cells from the GI tract, including bacteria that help to digest consumed food. Without an appendix, a person’s GI flora repopulate more slowly, and it’s unclear what effects that has on health.

Crowdsourcing the mapping of human microflora can be exactly the kind of complement that researchers need to advance the understanding of this complex problem. Sequencing all of the bacteria in the human body is a monumental task, akin to the Human Genome Project and its challenges. Since 2007, the NIH has been overseeing the Human Microbiome Project, an effort to sequence the microbiomes of 250 volunteers by 200 scientists worldwide. To do this, new kinds of data analysis methods are being developed, and it would be useful to test these against a larger, independent pool that uBiome could acquire. Understanding how bacterial flora relates to human health will likely be a diverse, multidecade endeavor that is full of surprises. Toward that effort, uBiome’s approach offers another way for people to both learn more about their bodies and contribute to important studies. Perhaps one day, we’ll be as equally (if not more) concerned about what the 90 percent of the non-human cells in our bodies are up to as we are about our own genomes. It seems fair since we are providing them room and board, after all.

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BACTERIAL POWER CORDS FOUND in SEABED

Bacterial Power Cables
Seen through an electron microscope, the Desulfobulbaceae — the researchers haven’t yet given them a genus or species name — appear in blue. They link end-to-end, forming filaments nearly an inch in length. {Image: Nils Risgaard-Petersen}

EXPLAINS CRACKLE
http://scitech.au.dk/en/current-affairs/news/show/artikel/living-cables-explain-enigmatic-electric-currents/

The enigma of electric currents in the seabed is solved. Scientists from Aarhus University have discovered bacteria that function as living electrical cables. Each of the centimetre-long ‘cable bacteria’ contains a bundle of insulated wires leading an electric current from one end to the other. Electricity and seawater are usually a bad mix. And it was thus a very big surprise when scientists from Aarhus University a few years ago discovered electric currents between biological processes in the seabed. Since then they have been searching for an explanation and together with partners from the University of Southern California, USA, they now present sensational results in Nature.

“Our experiments showed that the electric connections in the seabed must be solid structures built by bacteria,” says PhD student Christian Pfeffer, Aarhus University. He could interrupt the electric currents by pulling a thin wire horizontally through the seafloor. Just as when an excavator cuts our electric cables. In microscopes, scientists found a hitherto unknown type of long, multi-cellular bacteria that was always present when scientists measured the electric currents. “The incredible idea that these bacteria should be electric cables really fell into place when, inside the bacteria, we saw wire-like strings enclosed by a membrane,” says Nils Risgaard-Petersen, Aarhus University.

SQUARE KILOMETERS of LIVING CABLES
The bacterium is one hundred times thinner than a hair and the whole bacterium functions as an electric cable with a number of insulated wires within it. Quite similar to the electric cables we know from our daily lives. “Such unique insulated biological wires seem simple but with incredible complexity at nanoscale,” says PhD student Jie Song, Aarhus University, who used nanotools to map the electrical properties of the cable bacteria. In an undisturbed seabed more than tens of thousands kilometers cable bacteria live under a single square meter seabed. The ability to conduct an electric current gives cable bacteria such large benefits that it conquers much of the energy from decomposition processes in the seabed.

Unlike all other known forms of life, cable bacteria maintain an efficient combustion down in the oxygen-free part of the seabed. It only requires that one end of the individual reaches the oxygen which the seawater provides to the top millimeters of the seabed. The combustion is a transfer of the electrons of the food to oxygen which the bacterial inner wires manage over centimeter-long distances. However, small disturbances can lead to fatal “cable breakage” in the fragile bacteria. “On the one hand, it is still very unreal and fantastic. On the other hand, it is also very tangible,” says Professor at Aarhus University, Lars Peter Nielsen, who is in charge of exploring the natural electrical currents. Along with a number of international cooperation partners, several scientists at Aarhus University already address the new and exciting questions that arise. Right from the understanding of bioelectronics at the molecular level to the role of cable bacteria in the history of Earth. The future will tell whether this wondrous result of the biological evolution can also be used in new types of electronics.

Wiring Diagram
In the photo above, orange strands of the new Desulfobulbaceae stretch in a laboratory beaker between a reddish, oxygen-rich sediment layer and a dark, sulfurous, oxygen-depleted layer. This is the essential structure of much of the world’s seafloor, and one that the new Desulfobulbaceae evolved to exploit: One end feeds on hydrogen sulfide below, pulling out an electron that’s sent up the chain and, at the other end, is used to pull in oxygen. It’s a simple form of breathing. Water is generated as a byproduct. {Images: Nils Risgaard-Petersen}

NEW (OXYGEN-FREE) GENUS
http://www.wired.com/wiredscience/2012/10/bacteria-electric-wires/
Electric Bugs: New Microbe Forms Living, Deep-Sea Power Cables
by Brandon Keim  /  October 24, 2012

The world’s deep sea floors are dark and airless places, but vast swaths may pulse gently with energy conducted through a type of newly discovered bacteria that forms living electrical cables.The bacteria were first detected in 2010 by researchers perplexed at chemical fluctuations in sediments from the bottom of Aarhus Bay in Denmark. Almost instantaneously linking changing oxygen levels in water with reactions in mud nearly an inch below, the fluctuations occurred too fast to be explained by chemistry. Only an electrical signal made sense — but no known bacteria could transmit electricity across such comparatively vast distances. Were bacteria the size of humans, the signals would be making a journey 12 miles long. Now the mysterious bacteria have been identified. They belong to a microbial family called Desulfobulbaceae, though they share just 92 percent of their genes with any previously known member of that family. They deserve to be considered a new genus, the study of which could open a new scientific frontier for understanding the interface of biology, geology and chemistry across the undersea world. The bacteria are described Oct. 24 in Nature by researchers led by microbiologists Christian Pfeffer, Nils Risgaard-Petersen and Lars Peter Nielsen of Aarhus University. On the following pages, Wired takes a look at these marvelous microbes.

Live Wire
{Image: Karen E. Thomsen}

The new Desulfobulbaceae, seen in cross-section above, has a shape seemingly adapted to conducting electricity. Down each bacterium run deep channels, which are aligned continuously as the bacteria join into one long filament. It’s through these channels that electrons likely course. (This is still speculation, albeit informed — the bacteria clearly transfer electrons, but the exact route hasn’t been mapped.) The walls of the channels and a surrounding membrane may have insulating properties, like sheathing around a wire.

A Single Organism
{Image: Mingdong Dong}

A Single Organism: Each filament of the new Desulfobulbaceae doesn’t merely represent the end-to-end alignment of many individual microbes, but should be a considered a single multicellular organism, said Nielsen.

Electric Ecology
{Image: Nils Risgaard-Petersen}

In just one teaspoon of mud, the researchers found a full half-mile of Desulfobulbaceae cable, and it’s not just a Danish phenomenon. Nielsen said other researchers have sent him samples from seafloors around the world, including Tokyo Bay. It’s possible that, at the microbial level, the deep seafloor is humming with current. With so much electricity being transferred, are other organisms tapping the lines? Might the Desulfobulbaceae be a power source for entire as-yet-unappreciated deep-sea microbial ecologies, which in turn shape some of the planet’s fundamental biogeochemical processes? That’s “an interesting possibility,” said Nielsen, but it’s still speculation. Less speculatively, the Desulfobulbaceae are definitely breaking down iron sulfides and carbonates in deeper sediment, while generating iron oxide and magnesium calcite at the surface, Nielsen said. The latter are important compounds for life in the oceans above, and ultimately on land. If the new Desulfobulbaceae are as widespread and populous as they seem, they could be an important component of life’s deep-time cycles.

What Next?
Study co-author Christian Pfeffer pulls a thin wire through the seabed, severing the electrical connections. {Image: Nils Risgaard-Petersen}

What Next?
In addition to ecological questions, the researchers next want to learn more about the new Desulfobulbaceae’s structure and physiology. ”These are exciting times for microbiologists,” wrote microbiologist Gemma Reguera of Michigan State University in a commentary accompanying the new study. “The present work reminds us — one more time — just how much more awaits discovery.”

{Citations: “Filamentous bacteria transport electrons over centimetre distances.” Christian Pfeffer, Steffen Larsen, Jie Song, Mingdong Dong, Flemming Besenbacher, Rikke Louise Meyer, Kasper Urup Kjeldsen, Lars Schreiber, Yuri A. Gorby, Mohamed Y. El-Naggar, Kar Man Leung, Andreas Schramm, Nils Risgaard-Petersen & Lars Peter Nielsen. Nature, Vol. 490, No. 7421, 25 Oct. 2012.
“Bacterial power cords.” By Gemma Reguera. Nature, Vol. 490, No. 7421, 25 Oct. 2012}

seafloor_current1
Image: At left, Nielsen measures current in the sediment sample; at right, a close-up view of the sediment. {Image: Nils Risgaard-Petersen}

BIOELECTRICAL ECOLOGY
http://www.wired.com/wiredscience/2010/02/electric-ocean-bacteria/
Deep-Sea Bacteria Form Avatar-Style Electrochemical Networks
by Brandon Keim  /  February 25, 2010

According to findings, bacteria appear to conduct electrical currents across the ocean floor, driving linked chemical reactions at relatively vast distances. Noticed only when reseachers happened to test sediment leftovers from another experiment, the phenomenon may add a new mechanism to Earth’s biogeochemistry. “The cycling of elements and life at the bottom of the sea, and in soil, and anywhere else you’re short of oxygen — this could help us understand those processes,” said microbiologist Lars Peter Nielsen of Denmark’s Aarhus University, co-author of the study, published Feb. 24 in Nature.

The original focus of Nielsen’s team wasn’t seafloor conductivity, but an especially interesting species of sulfur bacteria found on the floor of Aarhus Bay. To help quantify their chemical activity, the researchers kept a few beakers of seawater and sulfur bacteria-free sediment for comparison. After those experiments ended, the beakers were almost forgotten. Then, a few weeks later, the researchers noticed strange patterns of activity. Changing oxygen levels in water above the top sediment layer were almost immediately followed by chemical fluctuations several layers down. The distance was so great, and the response time so quick, that usual methods of chemical transport — molecular diffusion, or a slow drift from high to low concentration — couldn’t explain it. At first, the researchers were stumped. Then they realized the process made sense if bacteria in the top and bottom layers were linked. Anything that affected oxygen-processing bacteria up top would also affect the sulfide-eating microbes below. It would explain the apparent connection; and an electrical linkage would explain the speed. It would also boggle the mind.

“Such hypotheses would at one time have been considered heretical,” wrote Kenneth Nealson, a University of Southern California microbiologist, in an accompanying commentary in Nature. A half-inch gap “doesn’t seem like much of a distance. But to a bacterium it amounts to 10,000 body lengths, equivalent to about 20 kilometers (12 miles) in human terms.” In recent years, however, scientists have found species of microbes with outer membranes covered by electron-transporting enzymes, or studded with conductive, micrometer-scale filaments. These are used in driving experimental microbial fuel cells, and are known to be found in the Aarhus Bay mud. Those sediments also contain trace amounts of pyrite, an electrically conductive mineral. The top sediment layer also had a low concentration of hydrogen ions, something that could only be explained through an electrochemical reaction, with electrons conducted from a distance, said Nielsen.

Nealson called the findings “astonishing,” and said they “may be relevant to energy transfer and electron flow through many different environments.” They could eventually applied to bacteria-based schemes for bioremediation, carbon sequestration and energy production.

Citations: “Electric currents couple spatially separated biogeochemical processes in marine sediment.” By Lars Peter Nielsen, Nils Risgaard-Petersen, Henrik Fossing, Peter Bondo Christensen & Mikio Sayam. Nature, Vol. 463, No. 7284, February 25, 2010.

“Sediment reactions defy dogma.” By Kenneth H. Nealson. Nature, Vol. 463, No. 7284, February 25, 2010.

Electrifying_microbial_filaments
Microorganisms (purple) in the upper layers of marine sediments use oxygen (O2) that diffuses from sea water as an acceptor of electrons, which they produce in energy-generating metabolic reactions. As a result, other microbes (orange) in deeper, anoxic layers (where oxygen is scarce or absent) have to use other electron acceptors such as sulphate (SO42−) for growth. Transfer of electrons to oxygen results in the formation of water, whereas electron transfer to sulphate produces hydrogen sulphide (H2S), which is poisonous to many organisms. Pfeffer et al. provide evidence that long bacterial filaments could transport electrons generated when hydrogen sulphide is converted into sulphur (S) at the bottom of the sediments and use them to consume oxygen in the upper layers. {Image: Gemma Reguera/Nature}

LIVING POWER CABLES
http://www.kurzweilai.net/living-power-cables-discovered
Multicellular bacteria transmit electrons across relatively enormous distances / October 26, 2012

A multinational research team has discovered filamentous bacteria that function as living power cables that transmit electrons thousands of cell lengths away. The Desulfobulbus bacterial cells, which are only a few hundreds of a nanometer long each, are so tiny that they are invisible to the naked eye. And yet, under the right circumstances, they form a multicellular filament that can transmit electrons across a distance as large as 1 centimeter as part of the filament’s respiration and ingestion processes. “To move electrons over these enormous distances in an entirely biological system would have been thought impossible,” said Moh El-Naggar, assistant professor of physics at the USC Dornsife College of Letters, Arts and Sciences, and co-author of the Nature paper.

Aarhus University scientists had discovered a seemingly inexplicable electric current on the sea floor years ago. The new experiments revealed that these currents are mediated by a hitherto unknown type of long, multicellular bacteria that act as living power cables “Until we found the cables we imagined something cooperative where electrons were transported through external networks between different bacteria. It was indeed a surprise to realize, that it was all going on inside a single organism,” said Lars Peter Nielsen of the Aarhus Department of Bioscience, and a corresponding author of the Nature paper.


SEM image of four filamentous_Desulfobulbaceae bacteria cells {Image: Christian Pfeffer et al./Nature}

The team studied bacteria living in marine sediments that power themselves by oxidizing hydrogen sulfide. Cells at the bottom live in a zone that is poor in oxygen but rich in hydrogen sulfide, and those at the top live in an area rich in oxygen but poor in hydrogen sulfide. The solution? They form long chains that transport individual electrons from the bottom to the top, completing the chemical reaction and generating life-sustaining energy. “You have feeder cells on one end and breather cells on the other, allowing the whole living cable to survive,” El-Naggar said. Aarhus and USC researchers collaborated to use physical techniques to evaluate the long-distance electron transfer in the filamentous bacteria. El-Naggar and his colleagues had previously used scanning-probe microscopy and nanofabrication methods to describe how bacteria use nanoscale structures called “bacterial nanowires” to transmit electrons many body lengths away from cells. This research was funded by European Research Council, the Danish National Research Foundation, the Danish Foundation for Independent Research and the German Max Planck Society.

References
Gemma Reguera, Microbiology: Bacterial power cords, Nature, 2012, DOI: 10.1038/nature11638
Christian Pfeffer et al., Filamentous bacteria transport electrons over centimetre distances, Nature, 2012, DOI: 10.1038/nature11586


http://www.bme.duke.edu/news/3079

BIOELECTRIC BIOMIMICRY
http://www.telegraph.co.uk/science/roger-highfield/9627744/The-electrical-storm-gathering-in-biology.html
The electrical storm gathering in biology
by Roger Highfield /  23 Oct 2012

Today, biologists are realising that electricity is even more important than was hitherto thought – so much so that some are talking about a new bioelectrical revolution. It not only governs the contraction of our muscles and carries impulses through our nerves, but also holds the key to a host of illnesses, from the most intense migraines to cystic fibrosis. Last week, at a lecture in the Royal Institution, London, the Oxford University physiologist Frances Ashcroft explained how this revolution in bioelectricity has happened. While the electricity we use to power motors, make lights shine and bring our computers to life relies on electrons – the fundamental sub-atomic particles which carry electrical charge – the electricity in our bodies is carried by larger, more complex charged atoms, or ions, which are found in salts such as sodium chloride. While electricity in wires travels at the speed of light, (around 186,000 miles per second), electrical signals are carried around our bodies at a far slower (if still rapid) half a mile per second, or about 1800 mph.

As bioelectricity flashes in and out of our cells, it generates currents of a few picoamperes – about a hundred billionth of the current that makes a light bulb glow. Somehow, the ions carrying these currents have to find a way past the insulating greasy membrane that protects the watery contents of every cell. The realisation that cell membranes are studded with tiny pores (constructed from specific proteins), which allow the free movement of ions, dates back to in the 1950s and the pioneering studies of Alan Hodgkin and Andrew Huxley in Cambridge and Bernard Katz at University College London. These pores are ion channels, and they regulate all life, from the moment of conception until we draw our last breath. Indeed, according to Ashcroft, these channels are truly the “spark of life” – the title of her recent book on the subject. From the lashing of the sperm’s tail to the beating of our hearts, the craving for yet another chocolate, or the feel of the sun on your skin, everything is underpinned by ion channel activity.

In 1984, Ashcroft discovered an ion channel through which potassium ions leave cells and observed that it was closed by the breakdown of glucose, triggering the release of insulin. She was so excited that she did not sleep; the next morning, thought she had made a mistake. She hadn’t. Two decades later it was found that a rare childhood form of diabetes resulted from a defect in this channel and, in a remarkable twist, could be treated by taking pills called sulphonylureas, initially trialled as a treatment for typhoid. It turns out that faulty ion channels are actually responsible for a remarkably wide range of human and animal diseases. Pigs that shiver themselves to death, myotonic goats that stiffen so much they topple over when startled, humans with cystic fibrosis, epilepsy, heart arrhythmias or migraine – all are victims of ion channel dysfunction. Mutations in sodium channels, for example, underlie inherited forms of epilepsy (when an electrical storm erupts in the brain), migraine headaches, heart rhythm disturbances, paralysis, and some chronic pain syndromes. In the past few years, important clues to understanding what goes wrong, and how this can be fixed, have come from working out what ion channels look like.

Sodium channels – which allow sodium ions to pass – are found in “excitable” cells such as the neurons in your brain, or the cells found in heart muscle, or the nerve cells that carry signals of pain, hot or cold. Their atomic structure was only solved last year, by William Catterall’s team from the University of Washington in Seattle. Many drugs work by interacting with ion channels and knowing the shape of the protein, and what the drug-binding sites look like, is expected to stimulate the design of new chemicals, which can alter the protein’s structure. Poisons target ion channels, too. In the past few days, Sylvie Diochot and Anne Baron from the French National Centre for Scientific Research (CNRS) have reported a remarkable discovery. The venom of the black mamba, one of the world’s nastiest snakes, contains chemicals that block nerve ion channels. These chemicals, mambalgins, stop a specific type of ion channel found in pain cells from opening. By doing so, they relieve pain as effectively as morphine, without its side effects. Thanks to the second electrical revolution, expect a new generation of drugs to fine-tune the electrical workings of your heart, nerves and brain.

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GREENLAND is MELTING (AGAIN)

Satellites Observe Widespread Melting Event on Greenland

Color bar for Satellites Observe Widespread Melting Event on Greenland

 

and MELTING FAST
http://ngm.nationalgeographic.com/2010/06/melt-zone/greenland-animation
http://news.nationalgeographic.com/news/2008/06/080619-greenland-ice.html
http://earthobservatory.nasa.gov/IOTD/view.php?id=78607

Nearly the entire ice sheet covering Greenland—from its thin coastal edges to its two-mile-thick center—experienced some degree of melting for several days in July 2012. According to measurements from three satellites and an analysis by NASA and university scientists, an estimated 97 percent of the top layer of the ice sheet had thawed at some point in mid-July, the largest extent of surface melting observed in three decades of satellite observations. The data visualization above shows the extent of surface melting in Greenland on July 8 (left) and July 12, 2012 (right). The maps are based on observations from the Special Sensor Microwave Imager/Sounder (SSMI/S) on the U.S. Air Force’s DMSP satellite, from India’s OceanSat-2, and from the Moderate Resolution Imaging Spectroradiometer (MODIS) on NASA’s Terra and Aqua satellites. The satellites measure different physical properties at different scales, and they pass over Greenland at different times. Taken together, they provide a picture of an extreme melt event.

On July 8, satellites showed that about 40 percent of the ice sheet had undergone thawing at or near the surface. By July 12, the extent of melting spread dramatically beyond the norm. In the images above, areas classified as “probable melt” (light pink) correspond to sites where at least one satellite detected surface melting. Areas classified as “melt” (dark pink) correspond to sites where two or three satellites detected melting. Every summer, a fraction of the surface of the Greenland ice sheet naturally melts. At high elevations, most melt water quickly refreezes in place. Near the coast, some of the melt is retained by the ice sheet and the rest is lost to the ocean. In mid-July 2012, Son Nghiem of NASA’s Jet Propulsion Laboratory was analyzing radar data from the Indian Space Research Organisation’s Oceansat-2 satellite when he noticed that most of Greenland appeared to have undergone surface melting on July 12. “This was so extraordinary that at first I questioned the result,” said Nghiem. “Was this real or was it due to a data error?” Nghiem consulted with Dorothy Hall, who studies the surface temperature of Greenland from NASA’s Goddard Space Flight Center. She confirmed that MODIS showed unusually high temperatures over the ice sheet surface and that melt was extensive. Colleagues Thomas Mote of the University of Georgia and Marco Tedesco of the City University of New York also confirmed the melt with passive-microwave data from the DMSP.

The extreme melting coincided with an unusually strong ridge of warm air—a “heat dome”—over Greenland. The ridge was one in a series that dominated Greenland’s weather between May and July 2012. Even the area around Summit Station in central Greenland, which at two miles above sea level is near the highest point of the ice sheet, showed signs of melting. A National Oceanic and Atmospheric Administration weather station at Summit confirmed that air temperatures hovered above or within a degree of freezing for several hours from July 11 to July 12. Such pronounced melting at Summit and across the ice sheet has not occurred since 1889, according to ice cores analyzed by Kaitlin Keegan at Dartmouth College. “Ice cores from Summit show that melting events of this type occur about once every 150 years,” said Lora Koenig, a NASA scientist and member of the team analyzing the satellite data. “With the last one happening in 1889, this event is right on time. But if we continue to observe melting events like this in upcoming years, it will be worrisome.” “The Greenland ice sheet is a vast area with a varied history of change,” said Tom Wagner, NASA’s cryosphere program manager. “This event, combined with other natural but uncommon phenomena such as the large calving event earlier this week on Petermann Glacier, are part of a complex story.”

Some of those other “unprecedented” melt events at Greenland ice sheet summit. Figure 2 in 1994 Science paper. Caption:  The 100-year smoothed accumulation record from the GISP2 core for the period A.D. 500 to the present. The arrows show locations of visually identified melt layers in the ice core. Reference: Science 9 December 1994: Vol. 266 no. 5191 pp. 1680-1682 DOI: 10.1126/science.266.5191.1680 The Accumulation Record from the GISP2 Core as an Indicator of Climate Change Throughout the Holocene
The 100-year smoothed accumulation record from the GISP2 core for the period A.D. 500 to the present. The arrows show locations of visually identified melt layers in the ice core. [1994]

PRECEDENTED
http://www.wired.com/geekmom/2012/07/greenland-ice-sheet-melting/
by Patricia Vollmer / July 26, 2012

From 8 July to 12 July, Greenland’s surface transitioned from approximately 40% melted water to approximately 97%. That’s a lot of melting in not a lot of time. The first indications were seen while analyzing radar reflectivity data from the Indian Space Research Organisation’s (ISRO) Oceansat-2 satellite, then it was verified with temperature data from the American Moderate-resolution Imaging Spectroradiometer (MODIS) on NASA’s Terra and Aqua satellites. Scientists at NASA Goddard Space Flight Center verified that the MODIS data indicated unusually high temperatures during the second week of July over the landmass; these conditions coincided with an upper air high pressure system, the same large-scale phenomena that has caused the recent heat waves in the eastern United States.

A third satellite verification was brought in, thanks to analyses from the Special Sensor Microwave Imager (SSM/I) on the U.S. Air Force’s Defense Meteorological Satellite Program (DMSP) satellites.Several of the channels on the SSM/I imager are tuned to sense data through the atmosphere all the way to the surface of the earth, detecting whether the surface is dry, flooded, forested, ocean water, iced-over or thawed.

Finally, on-site weather observations at research stations throughout Greenland have verified the warmer temperatures that correlate with the surface ice melting. While this news is very significant in the climatology and glaciology community, some are going step further and are attempting to connect it with other indicators of climate change. The definitive answer to that question is not clear and many news outlets are doing a good job providing a balanced view of this news. Several points should be made about this news:

  • The media is using the term “unprecedented”. In fact, the NASA press release about this is using the term “unprecedented”. What is “unprecedented” about this news is the ability for the satellites to see the warming, and the speed with which that data can be seen by the scientists. The warming itself certainly is not unprecedented. Conditions supporting this were last measured directly in 1889, and ice core samples, which have the ability offer evidence of climate conditions over 100,000 years old, have indicated that vast warming occurs approximately every 150 years. For this to happen in 2012 is not unreasonable.
  • The satellites taking the measurements require some understanding regarding their capabilities and limitations. Greenland is unique in that there is very little else besides rock, ice, snow and water for measurement. So I’m more confident in Greenland’s data than I would be in many other locations. Sand, loam, clay, forests and urban areas can often make detection more difficult. The two satellites mentioned above that measure reflectivities of the land mass surface (Oceansat-2 and SSM/I) are only measuring a few centimeters deep. It essentially measures data that translates into water on the surface. So even if there’s a slight sheen of water for the satellites to sense, there could still be miles of ice directly underneath.  As soon as the temperatures dip below freezing again, it will freeze again.
  • Melting happens on Greenland every year at this time. The melting itself is not what’s unusual. It’s theamount of melting.  Temperatures have been measured as high as 42F this July at locations that rarely exceed freezing temperatures year-round, according to NASA scientist Tom WagnerSome media outlets are coming up with some pretty crazy headlines that might make readers believe Greenland has never experienced melting before.
  • Because we have more data than ever before to assess this current melting period, it’s difficult to compare it to the very limited data — point data, if you will — of all the previous melting events. Ice cores and temperature measurements are many kilometers apart.

photo by James Balog Meltwater from the surface of the ice sheet plunges into the darkness of a moulin

MEASURABLE
http://www.globalwarming.org/2012/07/26/the-greenland-ice-melt-should-we-be-alarmed/
by Marlo Lewis / July 26, 2012

How much ice is Greenland shedding, and what are the implications for global sea-level rise? A study published in Science magazine in 2006 by Scott Luthcke of NASA and colleagues used satellite gravity measurements to estimate annual net ice loss in Greenland from 2003 to 2005. The researchers estimated that the ice sheet gained 55 gigatons per year from snowfall at higher elevations and lost 155 gigatons per year at lower elevations, yielding a net annual ice loss of 101 gigatons. That translates into an annual loss of 27 cubic miles of ice per year, or 2,700 cubic miles per century. Sounds huge — until you compare it to Greenland’s total ice mass. The Greenland Ice Sheet holds 706,000 cubic miles of ice. So at the 2003-2005 ice loss rate, Greenland will lose less than 4/10th of 1% of its ice mass in the 21st century. Apocalypse not.

Pat Michaels reviews a more recent gravity measurement study (Wu. et al. 2010, published inNatureGeoscience) that estimates ice mass balances in both Greenland and Antarctica from 2002 to 2008. Similar to the Luthcke study, the Wu team finds that Greenland’s net ice loss is 104 gigatons per year. They also estimate that Antarctica is losing 87 gigatons per year.

SUMMIT STATION
http://dartmouthigert.wordpress.com/2012/07/21/new-summit-melt-layer/
New Summit Melt Layer
by Kaitlin Keegan / July 21, 2012

“I arrived at Summit Station on July 13th, while traveling with the Joint Science and Education Program (JSEP) for a short visit to the camp. When we arrived, Summit Station had been experiencing above freezing temperatures for multiple days prior to our arrival and a melt layer formed on the near surface snow. I have been studying the physical properties of the top layers of the ice, the firn, at Summit and NEEM for my Ph.D. research. Recently, I have been focused on the melt layers present in both firn cores because they occur very infrequently. At Summit, there is only one other melt layer besides the melt layer from this past week and this previous melt layer dates to 1889. The most interesting part of being at Summit Station just after a melt event had occurred, is that the melt layer formation process could be observed. When studying a firn core, there is only a small cross section of the firn column that can be examined, which makes it hard to understand how the melt layer formed and how evenly distributed it is. Studying snow pits at Summit, including the recent melt layer, presents a unique opportunity for us to understand how previous melt events occurred. While at Summit density, stratigraphy, and permeability measurements have been taken and samples will also be brought back to the laboratory at Dartmouth, which will give us a clue about melt layers in the past.”

MELTWATER
http://www.guardian.co.uk/environment/2012/jul/25/greenland-glacier-bridge-destroyed-video?intcmp=239
Scientists in Kangerlussuaq on western edge of ice sheet film runoff from glacier washing out roads and taking out a tractor
by Suzanne Goldenberg / 25 July 2012

The gust of warm air that caused the unprecedented thaw inGreenland‘s surface ice also appears to have caused unusually high runoff from a glacier, wiping out a crossing near a key research and transport hub. Scientists who fly in Kangerlussuaq, near the western edge of the ice sheet, have been keeping an eye on the Watson river bridge for years. The bridge dates from the 1950s, but wasn’t built for the magnitude of spring and summer melt of the last 12 years or so, said Jason Box, a glaciologist at Ohio State University who returned on Tuesday from a three-week stint in Greenland. “The midsummer floods have been growing and threatening this bridge and finally took it out,” he said. “It washed out roads and took out a tractor.”

The river is fed by the nearby Russell Glacier, which sits just outside of town. Unlike other glaciers, which are exposed to the warming ocean waters, it sits entirely on land. Box, who works extensively in Greenland, has publicly warned that the ice melt is accelerating, in part because the snow and ice are losing their reflective capabilities. It was T-shirt weather some days in Greenland this month, he said. Such warms days were not unheard of though, he added.

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QUANTUM COMMUNICATION

Quantum entanglement (kinda)

FIRST NODES of a QUANTUM INTERNET
http://www.scientificcomputing.com/news-DS-First-Elementary-Quantum-Network-Based-on-Single-Atom-and-Photon-Interfaces-041112.aspx
http://www.extremetech.com/extreme/125885-the-first-universal-quantum-network-built-in-germany
The first universal quantum network
by  / April 12, 2012

German scientists at the Max Planck Institute of Quantum Optics (MPQ) have created the first “universal quantum network” that could be feasibly scaled up to become a quantum internet. So far their quantum network only spans two labs spaced 21 meters apart, but the scientists stress that longer distances and multiple nodes are possible. The network’s construction is ingenious. Each node is represented by a single rubidium atom, trapped inside a reflective optical cavity. These atoms communicate with each other by emitting a single photon over an optical fiber. Each atom is a quantum bit — a qubit — and the polarization of the photon emitted carries the quantum state of the qubit. The receiving qubit absorbs the photon and takes on the quantum state of the transmitter. Voila: A network of qubits that can send, receive, and store quantum information. With this atom/photon setup, the scientists were able to perform a read/write operation between two labs, over a 60-meter run of optic fiber. There aren’t any photos of the equipment used, but I suspect we’re probably talking about very large machines to keep the rubidium atoms near absolute zero.

Historically the difficulty has been getting atoms and photons to interact — they’re both impossibly small, so getting them to collide is tricky. The reflective optical cavity solves this problem — the photon ricochets tens of thousands of times until it eventually collides — but even so, the MPQ scientists still only managed to successfully transfer quantum states 0.2% of the time. In another, probably more exciting test, the emitted photons were actually used to entangle the rubidium atoms. Entangled particles exactly mirror the quantum state of their partner, instantaneously and over any distance. Entangled qubits might be able to form the basis of a quantum network with zero latency over any distance, which would make it rather useful for the intergalactic Galnet that will eventually succeed the internet. The researchers hope that entanglement could be used to mitigate the fickleness of single photons. Back on Earth, though, the goal now is to improve on that 99.8% failure rate and to scale up the number of nodes. I wouldn’t get too excited just yet, but this advance from the Max Planck Institute could mean that quantum networks aren’t actually that far away. Like the internet, the first real quantum network will link up the world’s universities, laboratories, and military installations — and then, eventually, offices and homes.

Rubidium atom/photon quantum network

UNCRACKABLE
http://news.sciencemag.org/sciencenow/2012/04/physicists-create-first-long-distance.html
Physicists Create First Long-Distance Quantum Link
by Jim Heirbaut  /  11 April 2012

For more than a decade, physicists have been developing quantum-mechanical methods to pass secret messages without fear that they could be intercepted. But they still haven’t created a true quantum network—the fully quantum-mechanical analog to an ordinary telecommunications network in which an uncrackable connection can be forged between any two stations or “nodes” in a network. Now, a team of researchers in Germany has built the first true quantum link using two widely separated atoms. A complete network could be constructed by combining many such links, the researchers say. ”These results are a remarkable achievement,” says Andrew Shields, an applied physicist and assistant managing director at Toshiba Research Europe Ltd. in Cambridge, U.K., who was not involved in the work. “In the past, we have built networks that can communicate quantum information, but convert it into classical form at the network switching points. [The researchers] report preliminary experiments towards forming a network in which the information remains in quantum form.”

Quantum communication schemes generally take advantage of the fact that, according to quantum theory, it’s impossible to measure the condition or “state” of a quantum particle without disturbing the particle. For example, suppose Alice wants to send Bob a secret message. She can do the encrypting in a traditional way, by writing out the message in the form of a long binary number and zippering it together in a certain mathematical way with a “key,” another long stream of random 0s and 1s. Bob can then use the same key to unscramble the message. But first, Alice must send Bob the key without letting anybody else see it. She can do that if she encodes the key in single particles of light, or photons. Details vary, but schemes generally exploit the fact that an eavesdropper, Eve, cannot measure the individual photons without altering their state in some way that Alice and Bob can detect by comparing notes before Alice encodes and sends her message. Such “quantum key distribution” has already been demonstrated in networks, such as a large six-node network in Vienna in 2008, and various companies offer quantum key distribution devices. Such schemes suffer a significant limitation, however. Although the key is passed from node to node in a quantum fashion, it must be read out and regenerated at each node in the network, leaving the nodes vulnerable to hacking. So physicists would like to make the nodes of the network themselves fully quantum mechanical—say, by forming them out of individual atoms.

According to quantum mechanics, an atom can have only certain discrete amounts of energy depending on how its innards are gyrating. Bizarrely, an atom can also be in two different energy states—call them 0 and 1—at once, although that uncertain two-states-at-once condition “collapses” into one state or the other as soon as the atom is measured. “Entanglement” takes weirdness to its absurd extreme. Two atoms can be entangled so that both are in an uncertain two-ways-at-once state, but their states are perfectly correlated. For example, if Alice and Bob share a pair of entangled atoms and she measures hers and finds it in the 1 state, then she’ll know that Bob is sure to find his in the 1 state, too, even before he measures it. Obviously, Alice and Bob can generate a shared random key by simply entangling and measuring their atoms again and again. Crucially, if entanglement can be extended to a third atom held by Charlotte, then Alice and Charlotte can share a key. In that case, if Eve then tries to detect the key by surreptitiously measuring Bob’s atom, she’ll mess up the correlations between Alice’s and Charlotte’s atoms in a way that will reveal her presence, making the truly quantum network unhackable, at least in principle. But first, physicists must entangle widely separated atoms. Now, Stephan Ritter of the Max Planck Institute of Quantum Optics in Garching, Germany, and colleagues have done just that, entangling two atoms in separate labs on opposite sides of the street, as they report online today in Nature.

As simple as this may sound, the researchers still needed a complete lab room full of lasers, optical elements, and other equipment for each node. Each atom sat between two highly reflective mirrors 0.5 mm apart, which form an “optical cavity.” By applying an external laser to atom A, Ritter’s team caused a photon emitted by that atom to escape from its cavity and travel through a 60-meter-long optical fiber to the cavity across the street. When the photon was absorbed by atom B, the original quantum information from the first atom was transferred to the second. By starting with just the right state of the first atom, the researchers could entangle the two atoms. According to the researchers, the entanglement could in principle be extended to a third atom, which makes the system scalable to more than two nodes. “Every experimental step had to be just right to make this work,” says Ritter, who works in the group of Gerhard Rempe. “Take, for example, the optical cavity. All physicists agree that atoms and photons are great stuff for building a quantum network, but in free space they hardly interact. We needed to develop the cavity for that.” ”This is a very important advance,” says Toshiba’s Shields, because it would enable technologists to share quantum keys on networks where the intermediate nodes can’t be trusted, and it could also lead to more complex multiparty communication protocols based on distributed entanglement. “However,” Shields cautions, “there is still a great deal of work to be done before the technology is practical.” Miniaturization of the components that constitute one node will no doubt be on the researchers’ wish list.

A quantum network built with two atoms and fiber optic cable

TWO ATOMS & a FIBER OPTIC CABLE
http://arstechnica.com/science/news/2012/04/a-quantum-network-built-with-two-atoms-and-fiber-optic-cable.ars
by 

An atom in an optical trap. Researchers have created a simple quantum network by linking two such atoms with fiber optic cable. A single photon passing between passes data. In an ordinary computer network, data in the form of binary numbers are transferred from one machine (node) to another via some sort of electronic signal, either electrical or optical. The success of this transfer comes when the recipient has precisely the same set of binary figures that were sent. In a quantum network, the “data” is a quantum state—the particular configuration of an atom’s energy, spin, etc.—and the transfer of information is successful if the state is reproduced in a separate quantum system some distance away.

Extant quantum networks are capable of either receiving or sending signals, but not both simultaneously. A new experiment reported by Stephan Ritter et al. in Nature has achieved a simple two-node quantum network, in which a single photon successfully transferred the spin state of one rubidium atom to a second atom 21 meters away. Since the nodes are identical, both being rubidium atoms, signals are bi-directional. This type of quantum network should be scalable to encompass more than two nodes, leading to the possibility of larger networks with full communication between arbitrary nodes within them.

The network was constructed by Ritter et al. at the Max Planck Institute for Quantum Optics. Each node consisted of a single neutral rubidium atom in an optical trap, which is a standing wave of laser light. Since this kind of trapping is very delicate, the entire system was cooled to 5 mK (5 thousandths of a degree above absolute zero) to minimize the chance that thermal fluctuations would kick the atom out. The researchers used a control laser to send a photon into the atom, which absorbed it and emitted a new photon. When this is done, the polarization (orientation of the electric field) of the second photon will be correlated with the spin state of the atom. To demonstrate that the information was actually carried by the photon, Ritter et al. used a polarized photon, and checked that the same information was present before and after interacting with the atom.

The key portion of the experiment, however, was to copy the quantum state of the first rubidium atom to the second. To accomplish this, Ritter et al. bounced the photon off their atom, then sent the emitted photon down a fiber optic cable 60 meters long to a second optical trap. (The extra cable length ensured that the coherence of the photon was maintained over greater distances than the space between the two optical traps.) The photon was then absorbed by the second atom, which set its spin state based on the photon’s polarization—which in turn was dictated by the spin state of the first atom. In this way, the “data” of the first node was passed to the second node, with an accuracy between 83 and 85 percent.

This is mostly a proof of concept, but it proves a lot of concepts. Since absorption and emission are both repeatable processes, there is no reason the same two atoms couldn’t be used to send and receive additional messages after the first transfer. Similarly, nothing changes if the atoms’ roles are swapped: the second node can just as easily act as the transmitter. Finally, nothing prevents a larger network of atoms from working in exactly the same way—the system is entirely scalable, although we’d face the problem of controlling which path through the network a particular photon should go.

In addition, after the photon exchange, the two atoms’ states may be correlated—entangled with each other. While this only occurs in 2 percent of the cases, it opens up the possibility of distributed quantum computing across the network, since the results of measurements performed on one atom will determine the outcome of measurements on the other, even across wide distances.

Nature, 2012. DOI: 10.1038/nature11023

Quantum network cartoon
Networks based on single atoms, linked by the exchange of single photons, could form the basis of versatile quantum networks. {Image: Andreas Neuzner/M.P.Q.}

ENTANGLEMENT
http://www.scientificamerican.com/article.cfm?id=universal-quantum-network
Physicists demonstrate a scalable quantum network that ought to be adaptable for all manner of long-distance quantum communication
First Universal Quantum Network Prototype Links 2 Separate Labs
by John Matson  /  April 11, 2012

Physicists have cleared a bit more of the path to a plausible quantum future by constructing an elementary network for exchanging and storing quantum information. The network features two all-purpose nodes that can send, receive and store quantum information, linked by a fiber-optic cable that carries it from one node to another on a single photon. The network is only a prototype, but if it can be refined and scaled up, it could form the basis of communication channels for relaying quantum information. A group from the Max Planck Institute of Quantum Optics (M.P.Q.) in Garching, Germany,described the advance in the April 12 issue of Nature.

Quantum bits, or qubits, are at the heart of quantum information technologies. An ordinary, classical bit in everyday electronics can store one of two values: a 0 or a 1. But thanks to the indeterminacy inherent to quantum mechanics, a qubit can be in a so-called superposition, hovering undecided between 0 and 1, which adds a layer of complexity to the information it carries. Quantum computers would boast capabilities beyond the reach of even the most powerful classical supercomputers, and cryptography protocols based on the exchange of qubits would be more secure than traditional encryption methods. Physicists have used all manner of quantum objects to store qubits—electrons, atomic nuclei, photons and so on. In the new demonstration, the qubit at each node of the network is stored in the internal quantum state of a single rubidium atom trapped in a reflective optical cavity. The atom can then transmit its stored information via an optical fiber by emitting a single photon, whose polarization state carries the mark of its parent atom’s quantum state; conversely, the atom can absorb a photon from the fiber and take on the quantum state imprinted on that photon’s polarization.

Because each node can perform a variety of functions—sending, receiving or storing quantum information—a network based on atoms in optical cavities could be scaled up simply by connecting more all-purpose nodes. “We try to build a system where the network node is universal,” says M.P.Q. physicist Stephan Ritter, one of the study’s authors. “It’s not only capable of sending or receiving—ideally, it would do all of the things you could imagine.” The individual pieces of such a system had been demonstrated—atoms sending quantum information on single emitted photons, say—but now the technologies are sufficiently advanced that they can work as an ensemble. “This has now all come together and enabled us to realize this elementary version of a quantum network,” Ritter says.

Physicists proposed using optical cavities for quantum networks 15 years ago, because they marry the best features of atomic qubits and photonic qubits—namely that atoms stay put, making them an ideal storage medium, whereas photons are speedy, making them an ideal message carrier between stationary nodes. But getting the photons and atoms to communicate with one another has been a challenge. “If you want to use single atoms and single photons, as we do, they hardly interact,” Ritter adds. That is where the optical cavity comes in. The mirrors of the cavity reflect a photon past the rubidium atom tens of thousands of times, boosting the chances of an interaction. “During this time, there’s enough time to really do this information exchange in a reliable way,” Ritter says. “The cavity enhances the coupling between the light field and the atom.”

The M.P.Q. group put their prototype network through a series of tests—transferring a qubit from a single photon to a single atom and reversing the process to transfer information from an atom onto a photon. Combining those read/write operations, the physicists managed to transmit a qubit from one rubidium atom to another located in a separate laboratory 21 meters away, using a messenger photon as the carrier between nodes. (The actual length of optical fiber connecting the two nodes is 60 meters, because it snakes along an indirect route.) A significant number of the photons get lost along the way, limiting the efficiency of the process. But in principle, optical fibers could connect nodes at greater distances. “We’re absolutely not limited to these 21 meters,” Ritter says. “This 21 meters is just the distance that we happened to have between the two labs.”

The researchers also demonstrated that their photonic link can be used to entanglethe two distant atoms. Quantum entanglement is a phenomenon by which two particles share correlated properties—in other words, the quantum state of one particle depends on the state of its entangled partner. Manipulating one of the particles, then, affects the other particle’s state, even if it is located in another laboratory. Researchers hope that entanglement can be harnessed to circumvent the photon losses that come from passage through optical fibers. In a proposed application called a quantum repeater, a series of nodes, linked by entanglement, would extend the quantum connection down the line without depending on any one photon as the carrier. Ritter acknowledges that the new work is simply a prototype, and one for which numerous improvements are possible. For instance, the transfer of a quantum state between labs succeeded only 0.2 percent of the time, owing to various inefficiencies and technical limitations. “Everything is at the edge of what can be done,” he says. “All these characteristics are good enough to do what we’ve done, but there are clear strategies to pursue to make them even better.”


http://iqc.uwaterloo.ca/news-events/archive/international-team-achieves-breakthrough-in-secure-quantum-computing
Artist’s rendition of ‘blind quantum computing’ achieved by Broadbent and collaborators

PRETTY WEIRD
http://www.pcmag.com/article2/0,2817,2402931,00.asp

Quantum networking is the practical application of experimental quantum cryptography, like the “blind quantum computing” demonstration by another team of researchers at the University of Vienna’s Center for Quantum Science and Technology earlier this year, which involved transmitting an algorithm to acomputer, running it, and receiving it back without the computer’s operator being able to snoop on those operations. Like its cousin, quantum computing, quantum networking takes advantage of the fact that subatomic particles of matter can exist in multiple states–such as “on” and “off” to reference the binary process by which digital computing operates–at the same time.

Again, this is exceedingly difficult stuff to wrap one’s head around, but suffice to say that these properties enable the quantum bits, or qubits, that power quantum computers and the single-photon data packets developed for the MPQ team’s quantum network to perform their duties much more powerfully and securely than the non-quantum parts used in currently available PC chips and network infrastructure devices. Of course, all of this is still very much in the realm of conjecture. Quantum computing is still highly theoretical, with demonstrations like the MPQ team’s limited to laboratory settings. There are no practical quantum computers,just experimental ones.


http://www.nature.com/nature/journal/v447/n7143/full/447372a.html

QUANTUM CRYPTOGRAPHY
http://www.pcmag.com/article2/0,2817,2399176,00.asp
Hacker Challenge: Crack Blind Quantum Computing, We Dare You
by Damon Poeter / January 20, 2012

Security professionals would balk at the notion of a computer code so perfectly unbreakable that you couldn’t crack it entering, exiting, or even performing its operations on a system, but a team of scientists says they’ve accomplished exactly that with what’s called “blind quantum computing.” The researchers, led by Stefanie Barz of the University of Vienna’s Center for Quantum Science and Technology, reported in Friday’s issue ofScience that they are able to transmit an algorithm to a computer, run it, and receive it back even as the computer’s operator is completely unable to snoop on those operations.

Quantum computing is still highly theoretical, with experiments in the science and its cousin, quantum cryptography, limited to laboratory settings—there are no practical quantum computers, just experimental ones. The basic concept is to use the odd nature of the entangled quantum bits, or qubits, that one uses to build a quantum computer to perform computational tasks much faster and much more securely than is possible on digital computers that use silicon transistors. At the exceedingly tiny level where quantum mechanics operates, particles of matter can exist in multiple states—such as “on” and “off” to reference the binary process by which digital computing operates—at the same time. We may not be able to comprehend what this means outside of mathematics, but scientists have theorized for several decades that harnessing these properties for computing would be a natural way past the issues that loom for today’s nanoscale silicon-based transistors, which are running up against atomic-level barriers to functionality the smaller they get.

While other researchers have described a blind quantum computing protocol, Barz’s team appears to be the first to have actually demonstrated one working. The researchers from Austria, Ireland, Singapore, Canada, and the U.K. write that their findings could pave the way for “unconditionally secure quantum cloud computing.” The team reports that it was able to “exploit the conceptual framework of measurement-based quantum computation that enables a client to delegate a computation to a quantum server” and thus create input, computation, and output processes on the target system in such a way that it “all remain[s] unknown to the computer.”

In less rarified terms, what this means is that in the future you might be able to use a cloud service like Google Docs to do some computational business on someone else’s servers, secure in the knowledge that there is literally no way for the servers’ owner or even the server itself to detect what you’re doing. Thank the Uncertainty Principle for that—simply by observing a quantum computational operation, you would change it. In the case of Deutsch’s algorithm and Grover’s algorithm, which the researchers sent to their quantum computer to perform and then send back to them, it would mean that if you somehow could get a peek at those operations, the intelligibility of what was transpiring would be destroyed before you ever got a chance to look at it. And the process is actually blind going both ways. According to the scientists, whoever sent an algorithm to a quantum computer for it to perform wouldn’t be able to see inside that system either.

DOPED CRYSTALS
http://gajitz.com/entangled-exploit-doped-crystals-key-to-quantum-networks/
Entangled Exploit: Doped Crystals Key to Quantum Networks

We have known for quite some time that quantum storage and quantum communication could vastly improve our current communications technology, but it’s not an easy pursuit. Getting photons to do what we want them to do is even harder than you might expect, so until now quantum communication has been more or less an exercise in educated guessing. Lately,researchers at the University of Calgary along with partners at the German University of Paderborn have been pushing quantum networks closer and closer to reality. They figured out that by “doping” a lithium niobate crystal with rare earth ions and chilling it to -454 Fahrenheit, the crystals can store and retrieve information in entangled photons. It’s quantum memory, the first step toward super-fast and super-secure quantum computers.

Quantum computers make use of that “freaky” quantum phenomenon of entanglement, a fundamental connection between two or more photons that means whatever changes happen to one happen to all other entangled photons. In this study, researchers used the precisely-tuned crystals to produce entangled copies of photons. The crystals and the information-containing photons can be stored and retrieved at will, much in the way that bytes of information are stored in a conventional computer. In other words, information is more or less being stored on a crystal, making quantum networks seem nearly within our reach at last. Similar results were found in a separate study at the University of Geneva, suggesting that the teams are onto something provable.

ULTRACOLD RUBIDIUM
http://www.photonics.com/Article.aspx?AID=45202
http://www.nanowerk.com/news/newsid=24964.php
Atomic blockade: Technique efficiently creates single photons for quantum information processing / Apr 20th, 2012

Using lasers to excite just one atom from a cloud of ultra-cold rubidium gas, physicists have developed a new way to rapidly and efficiently create single photons for potential use in optical quantum information processing – and in the study of dynamics and disorder in certain physical systems. The technique takes advantage of the unique properties of atoms that have one or more electrons excited to a condition of near-ionization known as the Rydberg state. Atoms in this highly excited state – with a principal quantum number greater than 70 – have exaggerated electromagnetic properties and interact strongly with one another. That allows one Rydberg atom to block the formation of additional excited atoms within an area of 10 to 20 microns. That single Rydberg atom can then be converted to a photon, ensuring that – on average – only one photon is produced from a rubidium cloud containing hundreds of densely-packed atoms. Reliably producing a single photon with well known properties is important to several research areas, including quantum information systems.

The new technique was reported April 19 in Science Express (“Photons One-at-a-Time”), the rapid online publication of the journal Science. The research was supported by the National Science Foundation (NSF), and by the Air Force Office of Scientific Research (AFOSR). “We are able to convert Rydberg excitations to single photons with very substantial efficiency, which allows us to prepare the state we want every time,” explained Alex Kuzmich, a professor in the School of Physics at the Georgia Institute of Technology. “This new system offers a fertile area for investigating entangled states of atoms, spin waves and photons. We hope this will be a first step toward doing a lot more with this system.” Kuzmich and co-author Yaroslav Dudin, a graduate research assistant, have been studying quantum information systems that rely on mapping information from atoms onto entangled pairs of photons. But the Raman scattering technique they have been using to create the photons was inefficient and unable to provide the number of entangled photons needed for complex systems. “This new photon source is about a thousand times faster than existing systems,” Dudin said. “The numbers are very good for our first experimental implementation.”

To create a Rydberg atom, the researchers used lasers to illuminate a dense ensemble of several hundred rubidium 87 atoms that had been laser-cooled and confined in an optical lattice. The illumination boosted a single atom from the entire cloud into the Rydberg state. Atoms excited to the Rydberg state strongly interact with other Rydberg atoms, and under suitable conditions, modify the atomic level energies and prevent more than one atom from being transferred into this state – a phenomenon known as the Rydberg blockade. Rydberg atoms show this strong interaction within a range of 10 to 20 microns. By limiting their starting ensemble of rubidium atoms to approximately that distance, Kuzmich and Dudin were able to ensure that no more than one such atom could form. “The excited Rydberg atom needs space around it and doesn’t allow any other Rydberg atoms to come nearby,” Dudin explained. “Our ensemble has a limited volume, so we couldn’t fit more than one of these atoms into the space available.” Kuzmich and Dudin have been using Rydberg atoms with a principal quantum number of approximately 100. These excited atoms are much larger – as much as a half-micron in diameter – than ground state rubidium atoms, which have a quantum number of 5 and a diameter of a few Angstroms.

>Once a highly excited atom was created, the researchers used an additional laser field to convert the excitation into a quantum light field that has the same statistical properties as the excitation. Because the field was produced by a single Rydberg atom, it contained just one photon, which can be used in a variety of protocols. For the Georgia Tech group, the next goal may be development of a quantum gate between light fields. The quantum gating of photons has been proposed and pursued by many research groups, so far unsuccessfully. “If this can be realized, such quantum gates would allow us to deterministically create complex entangled states of atoms and light, which would add valuable capabilities to the fields of quantum networks and computing,” Kuzmich said. “Our work points in this direction.” Beyond quantum information systems, the new single-photon system could also help scientists investigating other areas of physics. “Our results also hold promise for studies of dynamics and disorder in many-body systems with tunable interactions,” Kuzmich explained. “In particular, translational symmetry breaking, phase transitions and non-equilibrium many-body physics could be investigated in the future using strongly-coupled Rydberg excitations of an atomic gas.”

The single-photon work complements research being done in the Kuzmich lab on long-lived quantum memories. A new Air Force Office of Scientific Research Multidisciplinary University Research Initiative (MURI) was recently awarded to a consortium of seven U.S. universities that will work together to determine the best approach for generating quantum memories based on interaction between light and matter. Georgia Tech leads the MURI. “With this new work, we have demonstrated a new, deterministic source of single photons,” Kuzmich said. “In its first experimental realization, it already out-performs other types of single photons that have been pursued during the past decade around the world, including in our group. With further increases in efficiency and generation rate – and integration with long-lived quantum memories being developed in related work – such a single-photon source may make possible optical quantum information processing.”

BETWEEN MATTER and ANTI-MATTER
http://www.sciencedaily.com/releases/2012/04/120413160004.htm
On the Border Between Matter and Anti-Matter: Nanoscientists Find Long-Sought Majorana Particle / Apr. 13, 2012

Scientists at TU Delft’s Kavli Institute and the Foundation for Fundamental Research on Matter (FOM Foundation) have succeeded for the first time in detecting a Majorana particle. In the 1930s, the brilliant Italian physicist Ettore Majorana deduced from quantum theory the possibility of the existence of a very special particle, a particle that is its own anti-particle: the Majorana fermion. That ‘Majorana’ would be right on the border between matter and anti-matter.
Nanoscientist Leo Kouwenhoven already caused great excitement among scientists in February by presenting the preliminary results at a scientific congress. Today, the scientists have published their research in Science. The research was financed by the FOM Foundation and Microsoft.

Quantum computer and dark matter
Majorana fermions are very interesting — not only because their discovery opens up a new and uncharted chapter of fundamental physics; they may also play a role in cosmology. A proposed theory assumes that the mysterious ‘dark matter’, which forms the greatest part of the universe, is composed of Majorana fermions. Furthermore, scientists view the particles as fundamental building blocks for the quantum computer. Such a computer is far more powerful than the best supercomputer, but only exists in theory so far. Contrary to an ‘ordinary’ quantum computer, a quantum computer based on Majorana fermions is exceptionally stable and barely sensitive to external influences.

Nanowire
For the first time, scientists in Leo Kouwenhoven’s research group managed to create a nanoscale electronic device in which a pair of Majorana fermions ‘appear’ at either end of a nanowire. They did this by combining an extremely small nanowire, made by colleagues from Eindhoven University of Technology, with a superconducting material and a strong magnetic field. “The measurements of the particle at the ends of the nanowire cannot otherwise be explained than through the presence of a pair of Majorana fermions,” says Leo Kouwenhoven.

Particle accelerators
It is theoretically possible to detect a Majorana fermion with a particle accelerator such as the one at CERN. The current Large Hadron Collider appears to be insufficiently sensitive for that purpose but, according to physicists, there is another possibility: Majorana fermions can also appear in properly designed nanostructures. “What’s magical about quantum mechanics is that a Majorana particle created in this way is similar to the ones that may be observed in a particle accelerator, although that is very difficult to comprehend,” explains Kouwenhoven. “In 2010, two different groups of theorists came up with a solution using nanowires, superconductors and a strong magnetic field. We happened to be very familiar with those ingredients here at TU Delft through earlier research.” Microsoft approached Leo Kouwenhoven to help them lead a special FOM programme in search of Majorana fermions, resulting in a successful outcome..

Ettore Majorana
The Italian physicist Ettore Majorana was a brilliant theorist who showed great insight into physics at a young age. He discovered a hitherto unknown solution to the equations from which quantum scientists deduce elementary particles: the Majorana fermion. Practically all theoretic particles that are predicted by quantum theory have been found in the last decades, with just a few exceptions, including the enigmatic Majorana particle and the well-known Higgs boson. But Ettore Majorana the person is every bit as mysterious as the particle. In 1938 he withdrew all his money and disappeared during a boat trip from Palermo to Naples. Whether he killed himself, was murdered or lived on under a different identity is still not known. No trace of Majorana was ever found.

Elusive Majorana fermions may be lurking in a cold nanowire
A nanowire (silver color) is attached to a gold electrode and rests against a superconductor (blue). The combination produces quasiparticles that may be Majorana fermions.

MAJORANA FERMIONS
http://arstechnica.com/science/news/2012/04/experiment-may-have-found-majorana-fermions-in-a-nanowire.ars
Elusive Majorana fermions may be lurking in a cold nanowire
by 

Inside materials, the interactions between groups of electrons and atoms in the crystal lattice can give rise to a variety of interesting phenomena. Their collective behavior, especially at low temperatures, can give rise to quasiparticles: particle-like excitations that have strikingly different properties than the electrons that form them. Quasiparticles have been discovered that have behaviors predicted by particle physics, but have not been observed in particle collidors.

Researchers in the Netherlands have now produced quasiparticles that act like Majorana fermions: electrically-neutral particles that are their own antiparticles, such that if two collide, they annihilate. The existence of Majorana fermions was first predicted in the 1930s, but no individual particles are known to behave that way. V. Mourik et al. found a quasiparticle version by constructing a very thin wire—a nanowire—of semiconductor material and connected it to a superconductor. The specific electronic properties of the hybrid system gave rise to a pair of zero-velocity quasiparticles at two positions in the nanowire, and these showed behavior consistent with Majorana fermions. Some researchers suggest that quasiparticles of this type would be very useful in quantum computing applications.

Fermions vs. Bosons
Particles and quasiparticles come in two basic types, fermions and bosons, depending on the type of spin they have. The elementary particles of matter (electrons, quarks, and neutrinos) are fermions, while photons and other force carriers are bosons. Particles are paired with antiparticles—antimatter electrons are positrons, etc.—but photons are their own antiparticles. To annihilate, particles and antiparticles must have opposite charge, so Majorana fermions, which are their own antiparticles, need to be electrically-neutral. At present, no fermion is known to be its own antiparticle, although neutrinos may have this property (we don’t yet know).

Theorists predicted the existence of Majorana fermion quasiparticles in a materials known as topological superconductors, in which the interior of the material has zero electrical resistance, but the outside behaves like an ordinary conductor. To create a topological superconductor, Mourik et al. connected a semiconducting indium-antimony nanowire (InSb) between a gold electrode and the edge of a superconductor (NbTiN). They deposited the whole system onto a silicon substrate, which itself was printed with set of logic circuits that read the electronic properties of the wire.

By measuring the relationship between current and voltage at various positions along the nanowire, the researchers found a strong response at two points where the Majorana fermions are expected to appear. These quasiparticles didn’t move under the influence of either a magnetic field or an additional current, indicating that they are electrically neutral and trapped in place. This effect was strongest at 60 millikelvins (60 mK, which is 0.06 degrees above absolute zero) and vanished entirely at temperatures higher than 300 mK. Additionally, Mourik et al. confirmed that these Majorana quasiparticles failed to appear when the superconductor was replaced with another gold electrode, showing that the combination of the nanowire with the superconductor was necessary to create the fermions.

As the researchers themselves note, these results are consistent with Majorana fermions, but they have not been able to test for the presence of some of the predicted properties. Specifically, while the quasiparticles in the nanowire are electrically neutral and trapped at the expected positions, they should also behave in a certain way if their positions are swapped. While that can’t be directly tested in this device, this fundamental property of Majorana fermions can be tested using a superconducting device known as a Josephson junction, a standard technique.

Since the quantum states of Majorana quasiparticles in topological superconductors are not independent of each other, the total system represents a qubit (quantum bit), which has been proposed as another way to achieve working quantum computers (although that may be overselling them). Apart from that, from a pure physics point of view, this result is very important: if these quasiparticles indeed turn out to be Majorana fermions, that will be the first confirmed detection in any physical system.

Science, 2012. DOI: 10.1126/science.1222360  (About DOIs).

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MONSANTO-RESISTANT

SUPERWEEDS
http://www.sourcewatch.org/index.php?title=Monsanto_and_the_Roundup_Ready_Controversy
http://arkansasagnews.uark.edu/4364.htm
http://www.nytimes.com/2010/05/04/business/energy-environment/04weed.html
Farmers Cope With Roundup-Resistant Weeds
by William Neuman and Andrew Pollack / May 3, 2010

For 15 years, Eddie Anderson, a farmer, has been a strict adherent of no-till agriculture, an environmentally friendly technique that all but eliminates plowing to curb erosion and the harmful runoff of fertilizers and pesticides. But not this year. On a recent afternoon here, Mr. Anderson watched as tractors crisscrossed a rolling field — plowing and mixing herbicides into the soil to kill weeds where soybeans will soon be planted. Just as the heavy use of antibiotics contributed to the rise of drug-resistant supergerms, American farmers’ near-ubiquitous use of the weedkiller Roundup has led to the rapid growth of tenacious new superweeds.

To fight them, Mr. Anderson and farmers throughout the East, Midwest and South are being forced to spray fields with more toxic herbicides, pull weeds by hand and return to more labor-intensive methods like regular plowing. “We’re back to where we were 20 years ago,” said Mr. Anderson, who will plow about one-third of his 3,000 acres of soybean fields this spring, more than he has in years. “We’re trying to find out what works.” Farm experts say that such efforts could lead to higher food prices, lower crop yields, rising farm costs and more pollution of land and water. “It is the single largest threat to production agriculture that we have ever seen,” said Andrew Wargo III, the president of the Arkansas Association of Conservation Districts.

The first resistant species to pose a serious threat to agriculture was spotted in a Delaware soybean field in 2000. Since then, the problem has spread, with 10 resistant species in at least 22 states infesting millions of acres, predominantly soybeans, cotton and corn. The superweeds could temper American agriculture’s enthusiasm for some genetically modified crops. Soybeans, corn and cotton that are engineered to survive spraying with Roundup have become standard in American fields. However, if Roundup doesn’t kill the weeds, farmers have little incentive to spend the extra money for the special seeds.

Roundup — originally made by Monsanto but now also sold by others under the generic name glyphosate — has been little short of a miracle chemical for farmers. It kills a broad spectrum of weeds, is easy and safe to work with, and breaks down quickly, reducing its environmental impact. Sales took off in the late 1990s, after Monsanto created its brand of Roundup Ready crops that were genetically modified to tolerate the chemical, allowing farmers to spray their fields to kill the weeds while leaving the crop unharmed. Today, Roundup Ready crops account for about 90 percent of the soybeans and 70 percent of the corn and cotton grown in the United States. But farmers sprayed so much Roundup that weeds quickly evolved to survive it. “What we’re talking about here is Darwinian evolution in fast-forward,” Mike Owen, a weed scientist at Iowa State University, said.


At least 10 species of Roundup-resistant weeds have infested millions of acres in 22 states since 2000.

Now, Roundup-resistant weeds like horseweed and giant ragweed are forcing farmers to go back to more expensive techniques that they had long ago abandoned. Mr. Anderson, the farmer, is wrestling with a particularly tenacious species of glyphosate-resistant pest called Palmer amaranth, or pigweed, whose resistant form began seriously infesting farms in western Tennessee only last year. Pigweed can grow three inches a day and reach seven feet or more, choking out crops; it is so sturdy that it can damage harvesting equipment. In an attempt to kill the pest before it becomes that big, Mr. Anderson and his neighbors are plowing their fields and mixing herbicides into the soil.

That threatens to reverse one of the agricultural advances bolstered by the Roundup revolution: minimum-till farming. By combining Roundup and Roundup Ready crops, farmers did not have to plow under the weeds to control them. That reduced erosion, the runoff of chemicals into waterways and the use of fuel for tractors. If frequent plowing becomes necessary again, “that is certainly a major concern for our environment,” Ken Smith, a weed scientist at the University of Arkansas, said. In addition, some critics of genetically engineered crops say that the use of extra herbicides, including some old ones that are less environmentally tolerable than Roundup, belies the claims made by the biotechnology industry that its crops would be better for the environment. “The biotech industry is taking us into a more pesticide-dependent agriculture when they’ve always promised, and we need to be going in, the opposite direction,” said Bill Freese, a science policy analyst for the Center for Food Safety in Washington.

So far, weed scientists estimate that the total amount of United States farmland afflicted by Roundup-resistant weeds is relatively small — seven million to 10 million acres, according to Ian Heap, director of the International Survey of Herbicide Resistant Weeds, which is financed by the agricultural chemical industry. There are roughly 170 million acres planted with corn, soybeans and cotton, the crops most affected. Roundup-resistant weeds are also found in several other countries, including Australia, China and Brazil, according to the survey.

Monsanto, which once argued that resistance would not become a major problem, now cautions against exaggerating its impact. “It’s a serious issue, but it’s manageable,” said Rick Cole, who manages weed resistance issues in the United States for the company. Of course, Monsanto stands to lose a lot of business if farmers use less Roundup and Roundup Ready seeds. “You’re having to add another product with the Roundup to kill your weeds,” said Steve Doster, a corn and soybean farmer in Barnum, Iowa. “So then why are we buying the Roundup Ready product?”

Monsanto argues that Roundup still controls hundreds of weeds. But the company is concerned enough about the problem that it is taking the extraordinary step of subsidizing cotton farmers’ purchases of competing herbicides to supplement Roundup. Monsanto and other agricultural biotech companies are also developing genetically engineered crops resistant to other herbicides. Bayer is already selling cotton and soybeans resistant to glufosinate, another weedkiller. Monsanto’s newest corn is tolerant of both glyphosate and glufosinate, and the company is developing crops resistant to dicamba, an older pesticide. Syngenta is developing soybeans tolerant of its Callisto product. And Dow Chemical is developing corn and soybeans resistant to 2,4-D, a component of Agent Orange, the defoliant used in the Vietnam War.

Still, scientists and farmers say that glyphosate is a once-in-a-century discovery, and steps need to be taken to preserve its effectiveness. Glyphosate “is as important for reliable global food production as penicillin is for battling disease,” Stephen B. Powles, an Australian weed expert, wrote in a commentary in January in The Proceedings of the National Academy of Sciences. The National Research Council, which advises the federal government on scientific matters, sounded its own warning last month, saying that the emergence of resistant weeds jeopardized the substantial benefits that genetically engineered crops were providing to farmers and the environment.

Weed scientists are urging farmers to alternate glyphosate with other herbicides. But the price of glyphosate has been falling as competition increases from generic versions, encouraging farmers to keep relying on it. Something needs to be done, said Louie Perry Jr., a cotton grower whose great-great-grandfather started his farm in Moultrie, Ga., in 1830. Georgia has been one of the states hit hardest by Roundup-resistant pigweed, and Mr. Perry said the pest could pose as big a threat to cotton farming in the South as the beetle that devastated the industry in the early 20th century. “If we don’t whip this thing, it’s going to be like the boll weevil did to cotton,” said Mr. Perry, who is also chairman of the Georgia Cotton Commission. “It will take it away.”

ORDER 81
http://www.jonathanterranova.com/order81.php
http://www.alternet.org/world/62273/why_iraqi_farmers_might_prefer_death_to_paul_bremer’s_order_81/

STERILE SEED MONOPOLY
http://www.npr.org/templates/story/story.php?storyId=125906838
http://www.npr.org/templates/story/story.php?storyId=122498255
Monsanto GMO Ignites Big Seed War
by Frank Morris / January 12, 2010

Even though deep snowdrifts cover his fields in eastern Kansas, Luke Ulrich, a corn and soybean farmer here, is thinking about spring. It’s time to buy seed again, but hundreds of seed companies have gone under in the past two decades. Ulrich remembers the days before genetically modified seeds upended the industry. Critics of the big agriculture biotech company Monsanto say its popular Roundup Ready technology is to blame for that. Roundup Ready is a line of gene-modified seeds that inoculate plants against a herbicide, Roundup, also made by Monsanto, that kills just about everything else. “Ever since they’ve come out with the Roundup Ready trait and that became popular and basically took over farming, we’ve seen significant increases every single year,” Ulrich says. His seed costs shot up almost 50 percent last year. That’s because farmers are contractually prohibited from saving seeds and planting them the following year. Farmers face lawsuits if they try to save and replant the genetically modified seed because they don’t own the technology. While they bristle at that, they love the Roundup Ready seed. “There’s nothing like Roundup. A monkey could farm with it,” Ulrich says.

‘Amazing Amount Of Leverage’
More than 9 out of 10 soybean seeds carry the Roundup Ready trait. It’s about the same for cotton and just a little lower for corn. “Farmers will not buy soybeans without Roundup Ready in it. So, that gives Monsanto an amazing amount of leverage,” says Jim Denvir, a lawyer working for DuPont. DuPont owns Pioneer, a competing seed company. Pioneer licenses the Roundup Ready trait from Monsanto, as do about 150 other seed companies. Those agreements control which other genetics competing companies can mix with the Roundup Ready trait. Last year, Monsanto sued to stop Pioneer from “stacking” Roundup Ready with another trait. Denvir says Pioneer complained to the Justice Department. “A seed company can’t stay in business without offering seeds with Roundup Ready in it, so if they want to stay in that business, essentially they have to do what Monsanto tells them to do,” Denvir says.

Monsanto’s critics say it used this “platform monopoly” to crush many competitors. Chris Holman, a patent lawyer who teaches at the University of Missouri, Kansas City, likens it to Microsoft and its dominant Windows operating system. “Because of the structure of the industry, they are able to really drive participants in the industry into using their technology,” Holman says. Monsanto spokesman Lee Quarles says those allegations are unfair, though he concedes they’re coming at the company fast and furious. “We’re actively working to address questions from regulators, both the Department of Justice and state attorneys general as well as other parties in the industry, to address any questions they have about our business,” Quarles says. But Monsanto is pushing ahead. It will soon market a corn seed combining eight separate genetically engineered traits.

Roundup Ready 2 Yield
Roundup Ready technology was developed at Monsanto’s world headquarters in St. Louis. Jim Tobin, a vice president of Monsanto, says it sells itself. “Farmers get to vote every year before they plant, and it’s that vote each year that determines who has the largest market share or volume,” Tobin says. Monsanto spent huge amounts of money and took big risks to develop the Roundup Ready trait. Tobin says it has revolutionized agriculture. But now, “Well, we’ve invented something new,” he says. It’s called Roundup Ready 2 Yield. It uses the gene as the original, just placed in a different spot in the genome. Monsanto says that boosts yield. Interesting timing: Monsanto’s patent on Roundup Ready 1 expires in 2014 and with it, a revenue stream of maybe half a billion dollars a year in royalties. That’s unless it can switch farmers over to Roundup Ready 2. “We’d like to have everyone in the soybean business, seed business using the trait,” Tobin says.

Monsanto’s putting the new trait in all its best soybean seeds. And Paul Schickler, president of Pioneer, says Monsanto is forcing its licensees to do the same. He charges that Monsanto is trying to make Roundup Ready 1 disappear. “That’s our concern: bridging or switching from one patented product, Roundup Ready 1, to the next-generation Roundup Ready 2 Yield, doesn’t allow competition for the original technology,” Schickler says. Unlike in many other industries, there’s no clear path for a genetically modified crop to go generic. As it stands, generic providers would probably still need access to Monsanto’s proprietary data to get federal approval to sell the Roundup Ready trait. They’d also need closely held technical data to update licenses that keep the trait legal in big, important markets like China and the EU.

Meanwhile, the end of the Roundup Ready patent will very likely give farmers a chance to do something they haven’t for years: plant the seed they’ve harvested. Luke Ulrich is ready. “I don’t care how good Roundup Ready 2 is; if you tell me I can save back my own seed, I’m going to plant my own seed,” Ulrich says. The problem for guys like Ulrich will be finding seed that has just the Roundup Ready gene alone, one not stacked with other patented traits. After all, if he can’t find the seed in the first place, he can’t grow it.

NATURE PREDICTABLY DEFIANT
http://blogs.discovermagazine.com/loom/2010/05/04/how-to-make-a-superweed/
How To Evolve A Superweed

Around 1870, a tiny Chinese insect turned up in farm fields around the city of San Jose, California. The creature would inject a syringe-like mouthpart into a plant and suck up the juices. It grew a plate-like shield that covered its entire body, out from which new insects would eventually emerge. The San Jose scale, as the insect came to be known, spread quickly through the United States and Canada, leaving ravaged orchards in its path. “There is perhaps no insect capable of causing greater damage to fruit interests in the United States, or perhaps the world, than the San Jose scale,” one entomologist declared.

Farmers searched for pesticides that could stop the San Jose scale. In the nineteenth century, they had a fearsome arsenal of poisons for killing weeds and insects. In the ancient empire of Sumer 4500 years ago, farmers put sulfur on their crops. The Romans used pitch and grease. Europeans learned to extract chemicals from plants. In 1807, chemists isolated pyrethrum from an Armenian daisy. To stop the San Jose scale, they tried whale oil. They tried kerosene and water. One of the best treatments they found was a mix of lime and sulfur. After a few weeks of spraying, the San Jose scale would disappear.

By 1900, however, the lime-sulfur cure was failing. Here and there, the San Jose scale returned to its former abundance. An entomologist named A. L. Melander found some San Jose scales living happily under a thick crust of dried lime-sulfur spray. So Melander embarked on a widespread experiment, testing out sulfur-lime on orchards across Washington State. He found that in some orchards, the pesticide wiped out the insects completely. In other orchards, as many as 13 percent of the scales survived. But those surviving scales could be killed off with kerosene.

Melander wondered why some populations of scales were becoming able to resist pesticides. Could the sulfur-lime spray trigger a change in their biology, the way manual labor triggers the growth of callouses on our hands? Melander doubted it. After all, ten generations of scales lived and died between sprayings. The resistance must be hereditary, he reasoned. He sometimes would find families of scales still alive amidst a crowd of dead insects.

This was a radical idea at the time. Biologists had only recently rediscovered Mendel’s laws of heredity. They talked about genes being passed down from one generation to the next, yet they didn’t know what genes were made of yet. But they did recognize that genes could spontaneously change–mutate–and in so doing alter traits permanently. “The sporadic occurrence of naturally immune individual scales finds a parallel in recent work on heredity of protozoa and bacteria,” Melander declared in 1914. “Mutants less or not susceptible to certain toxins have been repeatedly found in cultures and from them have been produced immune strains.”

In the short term, Melander suggested that farmers switch to fuel oil to fight scales, but he warned that they would eventually become resistant to fuel oil as well. In fact, the best way to keep the scales from becoming entirely resistant to pesticides was, paradoxically, to do a bad job of applying those herbicides. By allowing some susceptible scales to survive, farmers would keep their susceptible genes in the scale population. “Thus we may make the strange assertion that the more faulty the spraying this year the easier it will be to control the scale the next year,” Melander predicted.

Melander is one of evolution’s unsung heroes. Nearly a century ago, he demonstrated how natural selection could happen very quickly, and have a direct effect on people’s lives. Unfortunately, his great insight appears to have fallen on deaf ears. For the next few decades, farmers and chemists gave little thought to the possibility that insects or weeds would evolve resistance. Gradually, however, it became clear that every time they tried a new chemical, the target of that chemical began to evolve resistance to it. And the more they sprayed a chemical, the faster the resistance evolved.

As chemicals failed, chemists searched for new ones. The search got harder and harder. Making the task more challenging was the fact that these chemicals can be extremely nasty not just to weeds or pests, but to beneficial insects, birds, and even humans. But in 1970 a scientist at the Monsanto Corporation found a chemical that seemed to hold out great hope–glyphosate, also known as Roundup. Glyphosate kills weeds by blocking the construction of amino acids that are essential for the survival of plants. It attacks enzymes that only plants use, with the result that it’s harmless to people, insects, and other animals. And unlike other herbicides that wind up in ground water, glyphosate stays where it’s sprayed, degrading within weeks.

Roundup went on the market in 1974. In 1986, scientists engineered plants to be resistant to glyphosate, by inserting genes from bacteria that could produce amino acids even after a plant was sprayed with herbicides. In the 1990s Monsanto and other companies began to sell glyphosate-resistant corn, cotton, sugar beets, and many other crops. The crops proved hugely popular. Instead of applying a lot of different herbicides, farmers found they could hit their fields with a modest amount of glyphosate alone, which wiped out weeds without harming their crops. Studies indicate that farmers who used the transgenic crops used fewer herbicides than those who grew regular plants —77% less in Mexico, for example—while getting a significantly higher yield from their fields.

For a while, it seemed as if glyphosate would avoid Melander’s iron rule. Monsanto scientists ran tests that showed no evidence of resistance. Glyphosate seemed to strike at such an essential part of plant biology that plants could not evolve a defense. But after glyphosate-resistant crops had a few years to grow, farmers began to notice horseweed and morning glory and other weeds encroaching once more into their fields. Farmers in Georgia had to cut down fields of cotton rather than harvest them because of infestations of Palmer amaranth.

In today’s New York Times William Neuman and Andrew Pollack have a sobering article about just how bad things have gotten for farmers who use glyphosate over the past decade. They begin with the story of one Tennessee farmer, Eddie Anderson: “For 15 years, Eddie Anderson, a farmer, has been a strict adherent of no-till agriculture, an environmentally friendly technique that all but eliminates plowing to curb erosion and the harmful runoff of fertilizers and pesticides. But not this year. On a recent afternoon here, Mr. Anderson watched as tractors crisscrossed a rolling field — plowing and mixing herbicides into the soil to kill weeds where soybeans will soon be planted. “What we’re talking about here is Darwinian evolution in fast-forward,” Mike Owen, a weed scientist at Iowa State University, told Neuman and Pollack.”

Neuman and Pollack left the story of this fast-forward evolution at that–but it’s actually a fascinating tale. A century ago, Melander could only study natural selection by observing which insects lived and died. Today, scientists can pop the lid off the genetic toolbox that insects and weeds use to resist chemicals that were once thought irresistible. Stephen Powles, a scientist at the University of Western Australia, has been studying the evolution of Roundup resistance for some years now, and he’s co-authored a new review that surveys what we know now about it.

What’s striking is how many different ways weeds have found to overcome the chemical. Scientists had thought that Roundup was invincible in part because the enzyme it attacks is pretty much the same in all plants. That uniformity suggests that plants can’t tolerate mutations to it; mutations must change its shape so that it doesn’t work and the plant dies. But it turns out that many populations of ryegrass and goosegrass have independently stumbled across one mutation that can change a single amino acid in the enzyme. The plant can still survive with this altered enzyme. And Roundup has a hard time attacking it thanks to its different shape.

Another way weeds fight off Roundup is through sheer numbers. Earlier this year an international team of scientists reported their discovery of how Palmer amaranth resists glyphosate. The plants make the ordinary, vulnerable form of the enzyme. But the scientists discovered that they have many extra copies of the gene for the enzyme–up to 160 extra copies, in fact. All those extra genes make extra copies of the enzyme. While the glyphosate may knock out some of the enzymes in the Palmer amaranth, the plants make so many more enzymes that they can go on growing.

It’s also possible for weeds to evolve resistance to Roundup without any change whatsoever to the enzyme Roundup attacks. When farmers spread Roundup on plants, the chemical spreads swiftly from the leaves all the way down the stems to the roots. This fast, widespread movement helps make Roundup so deadly. It turns out that some species of horseweed and other weeds have evolved a way to block the spread. Scientists don’t yet know how they manage this. It’s possible that cells in the leaves suck the Roundup in through their membranes and then tuck it away in safe little chambers where they can’t cause harm. However they do it, the weeds can continue to grow with their normal enzymes.

What makes the evolution of Roundup resistance all the more dangerous is how it doesn’t respect species barriers. Scientists have found evidence that once one species evolves resistance, it can pass on those resistance genes to other species. They just interbreed, producing hybrids that can then breed with the vulnerable parent species. In a recent interview, Powles predicted that the Roundup resistance catastophe is just going to get worse, not just in the United States but everywhere where Roundup is used intensively. It’s not a hopeless situation, however. Farmers may be able to slow the spread of resistance by mixing up the kinds of seeds they use, even by fostering vulernable weeds in the way Melander suggested. Resistance is a manageable problem–once you recognize the problem and its evolutionary roots.

SEED POLICE
http://www.treehugger.com/files/2008/09/michael-pollan-monsanto-google.php
http://www.vanityfair.com/politics/features/2008/05/monsanto200805
http://www.soilassociation.org/LinkClick.aspx?fileticket=6lQJZLPalqo%3d&tabid=390
http://seattletimes.nwsource.com/html/businesstechnology/2010504809_apusseedgiant.html
Monsanto seed biz role revealed
by Christopher Leonard / December 14, 2009

Confidential contracts detailing Monsanto Co.’s business practices reveal how the world’s biggest seed developer is squeezing competitors, controlling smaller seed companies and protecting its dominance over the multibillion-dollar market for genetically altered crops, an Associated Press investigation has found. With Monsanto’s patented genes being inserted into roughly 95 percent of all soybeans and 80 percent of all corn grown in the U.S., the company also is using its wide reach to control the ability of new biotech firms to get wide distribution for their products, according to a review of several Monsanto licensing agreements and dozens of interviews with seed industry participants, agriculture and legal experts. Declining competition in the seed business could lead to price hikes that ripple out to every family’s dinner table. That’s because the corn flakes you had for breakfast, soda you drank at lunch and beef stew you ate for dinner likely were produced from crops grown with Monsanto’s patented genes.

Monsanto’s methods are spelled out in a series of confidential commercial licensing agreements obtained by the AP. The contracts, as long as 30 pages, include basic terms for the selling of engineered crops resistant to Monsanto’s Roundup herbicide, along with shorter supplementary agreements that address new Monsanto traits or other contract amendments. The company has used the agreements to spread its technology – giving some 200 smaller companies the right to insert Monsanto’s genes in their separate strains of corn and soybean plants. But, the AP found, access to Monsanto’s genes comes at a cost, and with plenty of strings attached. For example, one contract provision bans independent companies from breeding plants that contain both Monsanto’s genes and the genes of any of its competitors, unless Monsanto gives prior written permission – giving Monsanto the ability to effectively lock out competitors from inserting their patented traits into the vast share of U.S. crops that already contain Monsanto’s genes.

Monsanto’s business strategies and licensing agreements are being investigated by the U.S. Department of Justice and at least two state attorneys general, who are trying to determine if the practices violate U.S. antitrust laws. The practices also are at the heart of civil antitrust suits filed against Monsanto by its competitors, including a 2004 suit filed by Syngenta AG that was settled with an agreement and ongoing litigation filed this summer by DuPont in response to a Monsanto lawsuit. The suburban St. Louis-based agricultural giant said it’s done nothing wrong. “We do not believe there is any merit to allegations about our licensing agreement or the terms within,” said Monsanto spokesman Lee Quarles. He said he couldn’t comment on many specific provisions of the agreements because they are confidential and the subject of ongoing litigation. “Our approach to licensing (with) many companies is pro-competitive and has enabled literally hundreds of seed companies, including all of our major direct competitors, to offer thousands of new seed products to farmers,” he said.

The benefit of Monsanto’s technology for farmers has been undeniable, but some of its major competitors and smaller seed firms claim the company is using strong-arm tactics to further its control. “We now believe that Monsanto has control over as much as 90 percent of (seed genetics). This level of control is almost unbelievable,” said Neil Harl, agricultural economist at Iowa State University who has studied the seed industry for decades. “The upshot of that is that it’s tightening Monsanto’s control, and makes it possible for them to increase their prices long term. And we’ve seen this happening the last five years, and the end is not in sight.”

At issue is how much power one company can have over seeds, the foundation of the world’s food supply. Without stiff competition, Monsanto could raise its seed prices at will, which in turn could raise the cost of everything from animal feed to wheat bread and cookies. The price of seeds is already rising. Monsanto increased some corn seed prices last year by 25 percent, with an additional 7 percent hike planned for corn seeds in 2010. Monsanto brand soybean seeds climbed 28 percent last year and will be flat or up 6 percent in 2010, said company spokeswoman Kelli Powers. Monsanto’s broad use of licensing agreements has made its biotech traits among the most widely and rapidly adopted technologies in farming history. These days, when farmers buy bags of seed with obscure brand names like AgVenture or M-Pride Genetics, they are paying for Monsanto’s licensed products.

One of the numerous provisions in the licensing agreements is a ban on mixing genes – or “stacking” in industry lingo – that enhance Monsanto’s power. One contract provision likely helped Monsanto buy 24 independent seed companies throughout the Farm Belt over the last few years: that corn seed agreement says that if a smaller company changes ownership, its inventory with Monsanto’s traits “shall be destroyed immediately.” Quarles, however, said Sunday he wasn’t familiar with that older agreement, obtained by the AP, but said, “as I understand it,” Monsanto includes provisions in all its contracts that allow companies to sell out their inventory if ownership changes, rather than force the firms to destroy the inventory immediately.

Another provision from contracts earlier this decade- regarding rebates – also help explain Monsanto’s rapid growth as it rolled out new products. One contract gave an independent seed company deep discounts if the company ensured that Monsanto’s products would make up 70 percent of its total corn seed inventory. In its 2004 lawsuit, Syngenta called the discounts part of Monsanto’s “scorched earth campaign” to keep Syngenta’s new traits out of the market. Quarles said the discounts were used to entice seed companies to carry Monsanto products when the technology was new and farmers hadn’t yet used it. Now that the products are widespread, Monsanto has discontinued the discounts, he said.

The Monsanto contracts reviewed by the AP prohibit seed companies from discussing terms, and Monsanto has the right to cancel deals and wipe out the inventory of a business if the confidentiality clauses are violated. Thomas Terral, chief executive officer of Terral Seed in Louisiana, said he recently rejected a Monsanto contract because it put too many restrictions on his business. But Terral refused to provide the unsigned contract to AP or even discuss its contents because he was afraid Monsanto would retaliate and cancel the rest of his agreements. “I would be so tied up in what I was able to do that basically I would have no value to anybody else,” he said. “The only person I would have value to is Monsanto, and I would continue to pay them millions in fees.”

Independent seed company owners could drop their contracts with Monsanto and return to selling conventional seed, but they say it could be financially ruinous. Monsanto’s Roundup Ready gene has become the industry standard over the last decade, and small companies fear losing customers if they drop it. It also can take years of breeding and investment to mix Monsanto’s genes into a seed company’s product line, so dropping the genes can be costly. Monsanto acknowledged that U.S. Department of Justice lawyers are seeking documents and interviewing company employees about its marketing practices. The DOJ wouldn’t comment.

A spokesman for Iowa Attorney General Tom Miller said the office is examining possible antitrust violations. Additionally, two sources familiar with an investigation in Texas said state Attorney General Greg Abbott’s office is considering the same issues. States have the authority to enforce federal antitrust law, and attorneys general are often involved in such cases. Monsanto chairman and chief executive officer Hugh Grant told investment analysts during a conference call this fall that the price increases are justified by the productivity boost farmers get from the company’s seeds. Farmers and seed company owners agree that Monsanto’s technology has boosted yields and profits, saving farmers time they once spent weeding and money they once spent on pesticides. But recent price hikes have still been tough to swallow on the farm. “It’s just like I got hit with bad weather and got a poor yield. It just means I’ve got less in the bottom line,” said Markus Reinke, a corn and soybean farmer near Concordia, Mo. who took over his family’s farm in 1965. “They can charge because they can do it, and get away with it. And us farmers just complain, and shake our heads and go along with it.”

Any Justice Department case against Monsanto could break new ground in balancing a company’s right to control its patented products while protecting competitors’ right to free and open competition, said Kevin Arquit, former director of the Federal Trade Commission competition bureau and now a antitrust attorney with Simpson Thacher & Bartlett LLP in New York. “These are very interesting issues, and not just for the companies, but for the Justice Department,” Arquit said. “They’re in an area where there is uncertainty in the law and there are consumer welfare implications and government policy implications for whatever the result is.” Other seed companies have followed Monsanto’s lead by including restrictive clauses in their licensing agreements, but their products only penetrate smaller segments of the U.S. seed market. Monsanto’s Roundup Ready gene, on the other hand, is in such a wide array of crops that its licensing agreements can have a massive effect on the rules of the marketplace.

Monsanto was only a niche player in the seed business just 12 years ago. It rose to the top thanks to innovation by its scientists and aggressive use of patent law by its attorneys. First came the science, when Monsanto in 1996 introduced the world’s first commercial strain of genetically engineered soybeans. The Roundup Ready plants were resistant to the herbicide, allowing farmers to spray Roundup whenever they wanted rather than wait until the soybeans had grown enough to withstand the chemical. The company soon released other genetically altered crops, such as corn plants that produced a natural pesticide to ward off bugs. While Monsanto had blockbuster products, it didn’t yet have a big foothold in a seed industry made up of hundreds of companies that supplied farmers. That’s where the legal innovations came in, as Monsanto became among the first to widely patent its genes and gain the right to strictly control how they were used. That control let it spread its technology through licensing agreements, while shaping the marketplace around them.

Back in the 1970s, public universities developed new traits for corn and soybean seeds that made them grow hardy and resist pests. Small seed companies got the traits cheaply and could blend them to breed superior crops without restriction. But the agreements give Monsanto control over mixing multiple biotech traits into crops. The restrictions even apply to taxpayer-funded researchers. Roger Boerma, a research professor at the University of Georgia, is developing specialized strains of soybeans that grow well in southeastern states, but his current research is tangled up in such restrictions from Monsanto and its competitors. “It’s made one level of our life incredibly challenging and difficult,” Boerma said.

The rules also can restrict research. Boerma halted research on a line of new soybean plants that contain a trait from a Monsanto competitor when he learned that the trait was ineffective unless it could be mixed with Monsanto’s Roundup Ready gene. Boerma said he hasn’t considered asking Monsanto’s permission to mix its traits with the competitor’s trait. “I think the co-mingling of their trait technology with another company’s trait technology would likely be a serious problem for them,” he said. Quarles pointed out that Monsanto has signed agreements with several companies allowing them to stack their traits with Monsanto’s. After Syngenta settled its lawsuit, for example, the companies struck a broad cross-licensing accord. At the same time, Monsanto’s patent rights give it the authority to say how independent companies use its traits, Quarles said. “Please also keep in mind that, as the (intellectual property developer), it is our right to determine who will obtain rights to our technology and for what purpose,” he said.

Monsanto’s provision requiring companies to destroy seeds containing Monsanto’s traits if a competitor buys them prohibited DuPont or other big firms from bidding against Monsanto when it snapped up two dozen smaller seed companies over the last five years, said David Boies, a lawyer representing DuPont who previously was a prosecutor on the federal antitrust case against Microsoft Corp. Competitive bids from companies like DuPont could have made it far more expensive for Monsanto to bring the smaller companies into its fold. But that contract provision prevented bidding wars, according to DuPont. “If the independent seed company is losing their license and has to destroy their seeds, they’re not going to have anything, in effect, to sell,” Boies said. “It requires them to destroy things – destroy things they paid for – if they go competitive. That’s exactly the kind of restriction on competitive choice that the antitrust laws outlaw.” Some independent seed company owners say they feel increasingly pinched as Monsanto cements its leadership in the industry. “They have the capital, they have the resources, they own lots of companies, and buying more. We’re small town, they’re Wall Street,” said Bill Cook, co-owner of M-Pride Genetics seed company in Garden City, Mo., who also declined to discuss or provide the agreements. “It’s very difficult to compete in this environment against companies like Monsanto.”

 

MEANWHILE : HEALTH CONCERNS
http://www.biolsci.org/v05p0706.htm
http://www.truthout.org/1215091
Study Proves Three Monsanto Corn Varieties’ Noxiousness to the Organism
by Le Monde with AFP / translation : Leslie Thatcher / 11.12.2009

A study published in the International Journal of Biological Sciences demonstrates the toxicity of three genetically modified corn varieties from the American seed company Monsanto, the Committee for Independent Research and Information on Genetic Engineering (Criigen, based in Caen), which participated in that study, announced Friday, December 11. “For the first time in the world, we’ve proven that GMO are neither sufficiently healthy nor proper to be commercialized. [...] Each time, for all three GMOs, the kidneys and liver, which are the main organs that react to a chemical food poisoning, had problems,” indicated Gilles-Eric Séralini, an expert member of the Commission for Biotechnology Reevaluation, created by the EU in 2008.

Caen and Rouen University researchers, as well as Criigen researchers, based their analyses on the data supplied by Monsanto to health authorities to obtain the green light for commercialization, but they draw different conclusions after new statistical calculations. According to Professor Séralini, the health authorities based themselves on a reading of the conclusions Monsanto has presented and not on conclusions drawn from the totality of the data. The researchers were able to obtain complete documentation following a legal decision. “Monsanto’s tests, effected over 90 days, are obviously not of sufficient duration to be able to say whether chronic illnesses are caused. That’s why we ask for tests over a period of at least two years,” explained one researcher. Consequently, the scientists demand a “firm prohibition” on the importation and cultivation of these GMOs. These three GMOs (MON810, MON863 and NK603) “are approved for human and animal consumption in the EU and especially the United States,” notes Professor Séralini. “MON810 is the only one of the three grown in certain EU countries (especially Spain); the others are imported,” he adds. A meeting of EU ministers over MON810 and NK603 is scheduled Monday.

FROM THE PEOPLE WHO BROUGHT YOU AGENT ORANGE (SEE ALSO : DEFOLIANTS)
http://www.monsanto.com/monsanto_today/for_the_record/agent_orange.asp
Agent Orange: Background on Monsanto’s Involvement

We have great respect for the U.S. soldiers sent to war and all those affected by the Vietnam conflict. All sides share in the pain from this difficult time in our history. One of the legacies of that war is Agent Orange, where questions remain nearly 40 years later. By way of background, the U.S. military used Agent Orange from 1961 to 1971 to save the lives of U.S. and allied soldiers by defoliating dense vegetation in the Vietnamese jungles and therefore reducing the chances of ambush.

As the war began and intensified, the U.S. government used its authority under the Defense Production Act to issue contracts to seven major chemical companies to obtain Agent Orange and other herbicides for use by U.S. and allied troops in Vietnam. The government specified the chemical composition of Agent Orange and when, where and how the material was to be used in the field, including application rates. Agent Orange was one of 15 herbicides used for military purposes during the Vietnam War and the most commonly applied. It received its name because of the orange band around containers of the material. The manufacturing companies included Diamond Shamrock Corporation, Dow Chemical Company, Hercules, Inc., T-H Agricultural & Nutrition Company, Thompson Chemicals Corporation, Uniroyal Inc. and Monsanto Company, which at the time was a chemical manufacturer. Monsanto manufactured Agent Orange from 1965 to 1969.

Agent Orange was a 50-50 mix of two common herbicides, 2,4-D and 2,4,5-T, which had been used domestically since the late 1940s without incident by U.S. farmers, railroads and others. Since the Vietnam War, both scientific and public concern has arisen over the dioxin compound 2,3,7,8-TCDD, a byproduct of the manufacturing process used to produce 2,4,5-T (which, again, was one of the herbicides in Agent Orange.) TCDD was present in trace amounts. Research on the issue of Agent Orange has gone on for decades and continues today.

There have been a number of lawsuits. Monsanto and the six other chemical manufacturers reached agreement with U.S. veterans in a class action lawsuit in U.S. District Court for the Eastern District of New York in 1984 that involved millions of U.S. veterans and their families. There was not a finding of fault. It was settled by the parties rather than undertake a lengthy and complicated trial. The $180 million in funds that were part of the agreement were distributed according to a plan developed in part by U.S. District Judge Jack B. Weinstein. There have been other lawsuits since that time. In March of 2009, a key legal question was settled in the United States when the U.S. Supreme Court let stand unanimous lower court rulings disallowing recovery from lawsuits on the Agent Orange issue. The Supreme Court agreed that the companies were not responsible for the implications of military use of Agent Orange in Vietnam, because the manufacturers were government contractors, carrying out the instructions of government.

Monsanto is now primarily a seed and agricultural products company. We believe that the adverse consequences alleged to have arisen out of the Vietnam War, including the use of Agent Orange, should be resolved by the governments that were involved.

The Congressional Research Service explored this issue in detail in May of 2009. It can be read at http://www.vn-agentorange.org/RL34761_200905.pdf

NO RECUSAL
http://www.scotuswiki.com/index.php?title=Monsanto_Company_v._Geertson_Seed_Farms
http://jurist.law.pitt.edu/paperchase/2010/04/supreme-court-hears-arguments-on_27.php
http://current.com/news/92330224_conflict-of-interest-ex-monsanto-lawyer-clarence-thomas-to-hear-major-monsanto-case.htm
Clarence Thomas, Former Monsanto Lawyer, Still Hearing Case

In Monsanto v. Geertson Seed Farms, No. 09-475, the U.S. Supreme Court will hear arguments in a case which could have an enormous effect on the future of the American food industry. This is Monsanto’s third appeal of the case, and if they win a favorable ruling from the high court, a deregulated Monsanto may find itself in position to corner the markets of numerous U.S. crops, and to litigate conventional farmers into oblivion. Here’s where it gets a bit dicier. Two Supreme Court justices have what appear to be direct conflicts of interest. Charles Breyer, the judge who ruled in the original decision of 2007 which is being appealed, is Stephen Breyer’s brother, who apparently views this as a conflict of interest and has recused himself. Meanwhile from the years 1976 – 1979, Clarence Thomas worked as an attorney for Monsanto. Thomas apparently does not see this as a conflict of interest and has not recused himself.

The lawsuit was filed by plantiffs which include the Center for Food Safety, the National Family Farm Coalition, Sierra Club, Dakota Resources Council and other farm, environmental and consumer groups and individual farmers. The original decision : “The federal district court in California issued its opinion on the deregulation of “Roundup Ready” alfalfa pursuant to the Plant Protection Act on February 13, 2007. Upon receiving Monsanto’s petition for deregulation of the alfalfa seed, APHIS conducted an Environmental Assessment and received over 500 comments in opposition to the deregulation. The opposition’s primary concern was the potential of contamination. APHIS, however, made a Finding of No Significant Impact (FONSI) and approved the deregulation petition, thereby allowing the seed to be sold without USDA oversight. Geertson Seed Farms, joined by a number of growers and associations, filed claims under the National Environmental Policy Act (NEPA) as well as the Endangered Species Act and Plant Protection Act. In regards to NEPA, they argued that the agency should have prepared an EIS for the deregulation.”

Addressing only the NEPA claims, the court agreed that APHIS should have conducted an EIS because of the significant environmental impact posed by deregulation of the alfalfa seed. A realistic potential for contamination existed, said the court, but the agency had not fully inquired into the extent of this potential. The court also determined that APHIS did not adequately examine the potential effects of Roundup Ready alfalfa on organic farming and the development of glyphosate-resistant weeds and that there were “substantial questions” raised by the deregulation petition that the agency should have addressed in an EIS. Concluding that the question of whether the introduction of the genetically engineered alfalfa and its potential to affect non-genetic alfalfa posed a significant environmental impact necessitated further study, the court found that APHIS’s decision was “arbitrary and capricious” and ordered the agency to prepare an EIS. The court later enjoined the planting of Roundup Ready alfalfa from March 30, 2007, until completion of the EIS and reconsideration of the deregulation petition, except for those farmers who had already purchased the seed. In May of 2007, the court enjoined any future planting of the alfalfa. An order by the court in June, 2007 required disclosure of all Roundup Ready planting sites. Monsanto filed appeals in 2008 and 2009. In both instances, they were unsuccessful in having the original decision reversed, so they appealed to the Supreme Court, who agreed to hear the case.

Alfalfa is the fourth most widely grown crop in the United States, behind corn, soybeans, and wheat. South Dakota alfalfa farmer Pat Trask, one of the plaintiffs, said Monsanto’s biotech alfalfa would ruin his conventional alfalfa seed business because it was certain his 9,000 acres would be contaminated by the biotech genes. Alfalfa is very easily cross-pollinated by bees and by wind. The plant is also perennial, meaning GMO plants could live on for years. “The way this spreads so far and wide, it will eliminate the conventional alfalfa industry,” said Trask. “Monsanto will own the entire alfalfa industry.”

Monsanto has a policy of filing lawsuits or taking other legal actions against farmers who harvest crops that show the presence of the company’s patented gene technology. It has sued farmers even when they have tried to keep their own fields free from contamination by biotech plants on neighbouring farms. The case has implications beyond alfalfa crops. About eight hundred reviewed genetically engineered food applications were submitted to the USDA, yet no environmental impact statements were prepared. Even as this diary is being written, a federal judge in San Francisco is reviewing a similar case involving genetically modified sugar beets. The decision is expected this week and could halt planting and use of the gm sugar beets, which account for half of America’s sugar supply.

SEEDS AS DEBT : INDIA’S ‘SUICIDE BELT’
http://www.sourcewatch.org/index.php?title=Monsanto_in_India
http://www.princeofwales.gov.uk/personalprofiles/theprinceofwales/initiatives/bhumi_vardaan_1602036119.html
http://www.microensure.com/about/our-products.aspx
http://www.democracynow.org/2006/12/13/vandana_shiva_on_farmer_suicides_the
http://www.dailymail.co.uk/news/worldnews/article-1082559/The-GM-genocide-Thousands-Indian-farmers-committing-suicide-using-genetically-modified-crops.html
When Prince Charles claimed thousands of Indian farmers were killing themselves after using GM crops, he was branded a scaremonger. In fact, it’s worse than he feared.
by Andrew Malone / 3rd November 2008

The children were inconsolable. Mute with shock and fighting back tears, they huddled beside their mother as friends and neighbours prepared their father’s body for cremation on a blazing bonfire built on the cracked, barren fields near their home. As flames consumed the corpse, Ganjanan, 12, and Kalpana, 14, faced a grim future. While Shankara Mandaukar had hoped his son and daughter would have a better life under India’s economic boom, they now face working as slave labour for a few pence a day. Landless and homeless, they will be the lowest of the low. Shankara, respected farmer, loving husband and father, had taken his own life. Less than 24 hours earlier, facing the loss of his land due to debt, he drank a cupful of chemical insecticide. Unable to pay back the equivalent of two years’ earnings, he was in despair. He could see no way out. There were still marks in the dust where he had writhed in agony. Other villagers looked on – they knew from experience that any intervention was pointless – as he lay doubled up on the ground, crying out in pain and vomiting. Moaning, he crawled on to a bench outside his simple home 100 miles from Nagpur in central India. An hour later, he stopped making any noise. Then he stopped breathing. At 5pm on Sunday, the life of Shankara Mandaukar came to an end. As neighbours gathered to pray outside the family home, Nirmala Mandaukar, 50, told how she rushed back from the fields to find her husband dead. ‘He was a loving and caring man,’ she said, weeping quietly. ‘But he couldn’t take any more. The mental anguish was too much. We have lost everything.’

Shankara’s crop had failed – twice. Of course, famine and pestilence are part of India’s ancient story. But the death of this respected farmer has been blamed on something far more modern and sinister: genetically modified crops. Shankara, like millions of other Indian farmers, had been promised previously unheard of harvests and income if he switched from farming with traditional seeds to planting GM seeds instead. Beguiled by the promise of future riches, he borrowed money in order to buy the GM seeds. But when the harvests failed, he was left with spiralling debts – and no income. So Shankara became one of an estimated 125,000 farmers to take their own life as a result of the ruthless drive to use India as a testing ground for genetically modified crops. The crisis, branded the ‘GM Genocide’ by campaigners, was highlighted recently when Prince Charles claimed that the issue of GM had become a ‘global moral question’ – and the time had come to end its unstoppable march. Speaking by video link to a conference in the Indian capital, Delhi, he infuriated bio-tech leaders and some politicians by condemning ‘the truly appalling and tragic rate of small farmer suicides in India, stemming… from the failure of many GM crop varieties’. Ranged against the Prince are powerful GM lobbyists and prominent politicians, who claim that genetically modified crops have transformed Indian agriculture, providing greater yields than ever before. The rest of the world, they insist, should embrace ‘the future’ and follow suit.

So who is telling the truth? To find out, I travelled to the ‘suicide belt’ in Maharashtra state. What I found was deeply disturbing – and has profound implications for countries, including Britain, debating whether to allow the planting of seeds manipulated by scientists to circumvent the laws of nature. For official figures from the Indian Ministry of Agriculture do indeed confirm that in a huge humanitarian crisis, more than 1,000 farmers kill themselves here each month. Simple, rural people, they are dying slow, agonising deaths. Most swallow insecticide – a pricey substance they were promised they would not need when they were coerced into growing expensive GM crops. It seems that many are massively in debt to local money-lenders, having over-borrowed to purchase GM seed. Pro-GM experts claim that it is rural poverty, alcoholism, drought and ‘agrarian distress’ that is the real reason for the horrific toll. But, as I discovered during a four-day journey through the epicentre of the disaster, that is not the full story.

In one small village I visited, 18 farmers had committed suicide after being sucked into GM debts. In some cases, women have taken over farms from their dead husbands – only to kill themselves as well. Latta Ramesh, 38, drank insecticide after her crops failed – two years after her husband disappeared when the GM debts became too much. She left her ten-year-old son, Rashan, in the care of relatives. ‘He cries when he thinks of his mother,’ said the dead woman’s aunt, sitting listlessly in shade near the fields. Village after village, families told how they had fallen into debt after being persuaded to buy GM seeds instead of traditional cotton seeds. The price difference is staggering: £10 for 100 grams of GM seed, compared with less than £10 for 1,000 times more traditional seeds.

But GM salesmen and government officials had promised farmers that these were ‘magic seeds’ – with better crops that would be free from parasites and insects. Indeed, in a bid to promote the uptake of GM seeds, traditional varieties were banned from many government seed banks. The authorities had a vested interest in promoting this new biotechnology. Desperate to escape the grinding poverty of the post-independence years, the Indian government had agreed to allow new bio-tech giants, such as the U.S. market-leader Monsanto, to sell their new seed creations. In return for allowing western companies access to the second most populated country in the world, with more than one billion people, India was granted International Monetary Fund loans in the Eighties and Nineties, helping to launch an economic revolution.

But while cities such as Mumbai and Delhi have boomed, the farmers’ lives have slid back into the dark ages. Though areas of India planted with GM seeds have doubled in two years – up to 17 million acres – many famers have found there is a terrible price to be paid. Far from being ‘magic seeds’, GM pest-proof ‘breeds’ of cotton have been devastated by bollworms, a voracious parasite. Nor were the farmers told that these seeds require double the amount of water. This has proved a matter of life and death. With rains failing for the past two years, many GM crops have simply withered and died, leaving the farmers with crippling debts and no means of paying them off. Having taken loans from traditional money lenders at extortionate rates, hundreds of thousands of small farmers have faced losing their land as the expensive seeds fail, while those who could struggle on faced a fresh crisis. When crops failed in the past, farmers could still save seeds and replant them the following year.

But with GM seeds they cannot do this. That’s because GM seeds contain so- called ‘terminator technology’, meaning that they have been genetically modified so that the resulting crops do not produce viable seeds of their own. As a result, farmers have to buy new seeds each year at the same punitive prices. For some, that means the difference between life and death. Take the case of Suresh Bhalasa, another farmer who was cremated this week, leaving a wife and two children. As night fell after the ceremony, and neighbours squatted outside while sacred cows were brought in from the fields, his family had no doubt that their troubles stemmed from the moment they were encouraged to buy BT Cotton, a geneticallymodified plant created by Monsanto. ‘We are ruined now,’ said the dead man’s 38-year-old wife. ‘We bought 100 grams of BT Cotton. Our crop failed twice. My husband had become depressed. He went out to his field, lay down in the cotton and swallowed insecticide.’

Villagers bundled him into a rickshaw and headed to hospital along rutted farm roads. ‘He cried out that he had taken the insecticide and he was sorry,’ she said, as her family and neighbours crowded into her home to pay their respects. ‘He was dead by the time they got to hospital.’ Asked if the dead man was a ‘drunkard’ or suffered from other ‘social problems’, as alleged by pro-GM officials, the quiet, dignified gathering erupted in anger. ‘No! No!’ one of the dead man’s brothers exclaimed. ‘Suresh was a good man. He sent his children to school and paid his taxes. ‘He was strangled by these magic seeds. They sell us the seeds, saying they will not need expensive pesticides but they do. We have to buy the same seeds from the same company every year. It is killing us. Please tell the world what is happening here.’ Monsanto has admitted that soaring debt was a ‘factor in this tragedy’. But pointing out that cotton production had doubled in the past seven years, a spokesman added that there are other reasons for the recent crisis, such as ‘untimely rain’ or drought, and pointed out that suicides have always been part of rural Indian life. Officials also point to surveys saying the majority of Indian farmers want GM seeds – no doubt encouraged to do so by aggressive marketing tactics.

During the course of my inquiries in Maharastra, I encountered three ‘independent’ surveyors scouring villages for information about suicides. They insisted that GM seeds were only 50 per cent more expensive – and then later admitted the difference was 1,000 per cent. (A Monsanto spokesman later insisted their seed is ‘only double’ the price of ‘official’ non-GM seed – but admitted that the difference can be vast if cheaper traditional seeds are sold by ‘unscrupulous’ merchants, who often also sell ‘fake’ GM seeds which are prone to disease.) With rumours of imminent government compensation to stem the wave of deaths, many farmers said they were desperate for any form of assistance. ‘We just want to escape from our problems,’ one said. ‘We just want help to stop any more of us dying.’ Prince Charles is so distressed by the plight of the suicide farmers that he is setting up a charity, the Bhumi Vardaan Foundation, to help those affected and promote organic Indian crops instead of GM.

India’s farmers are also starting to fight back. As well as taking GM seed distributors hostage and staging mass protests, one state government is taking legal action against Monsanto for the exorbitant costs of GM seeds. This came too late for Shankara Mandauker, who was 80,000 rupees (about £1,000) in debt when he took his own life. ‘I told him that we can survive,’ his widow said, her children still by her side as darkness fell. ‘I told him we could find a way out. He just said it was better to die.’ But the debt does not die with her husband: unless she can find a way of paying it off, she will not be able to afford the children’s schooling. They will lose their land, joining the hordes seen begging in their thousands by the roadside throughout this vast, chaotic country. Cruelly, it’s the young who are suffering most from the ‘GM Genocide’ – the very generation supposed to be lifted out of a life of hardship and misery by these ‘magic seeds’. Here in the suicide belt of India, the cost of the genetically modified future is murderously high.


anti-Monsanto crop circle made by farmers in the Philippines – photo by Melvyn Calderon

TRUST + ANTI-TRUST
http://www.laveudafrica.com/africa/Detarts.asp?id=273&t=Monsanto:+The+parable+of+the+sower.
Monsanto: The parable of the sower / The Economist / 11.2009

Few companies excite such extreme emotions as Monsanto. To its critics, the agricultural giant is a corporate hybrid of Victor Frankenstein and Ebenezer Scrooge, using science to create foods that threaten the health of both people and the planet, and intellectual-property laws to squeeze every last penny out of the world’s poor. The list of Monsanto’s sins dates back to when (with other firms) it produced Agent Orange, a herbicide notorious for its use by American forces in Vietnam. Recently “Food Inc”, a documentary film, lambasted the company. To its admirers, the innovations in seeds pioneered by Monsanto are the world’s best hope of tackling a looming global food crisis. Hugh Grant, the firm’s boss since 2003, says that without the sort of technological breakthroughs Monsanto has achieved the world has no chance of doubling agricultural output by 2050 while using less land and water, as many believe it must. Mr Grant, of course, would say that. But he is not alone. Bill Gates sees Monsanto’s innovations as essential to the agricultural revolution in Africa to which his charitable foundation is committed. Josette Sheeran, the head of the United Nations World Food Programme, is also a fan.

Monsanto has come a long way from its roots in pharmaceuticals and chemicals (in which capacity it made Agent Orange). The original company was formed in 1901 to make saccharine. In 2000 it merged with Pharmacia & Upjohn, a drugmaker. Two years later the group’s agricultural activities were spun off into a new Monsanto. At that time the company was best known for Roundup, a herbicide popular with farmers. Roundup is still a leading brand, but margins have been eroded by competition from Chinese producers of other forms of glyphosate weedkiller. Roundup’s share of Monsanto’s revenue is shrinking towards 10%. There is talk that it might be sold. “It is no sacred cow. We look at it every year,” says Mr Grant. Today most of Monsanto’s $11.7 billion of annual sales come from seeds, increasingly of genetically modified (GM), or transgenic, varieties, and from licensing genetic traits. Indeed, it is now best known, for better or worse, for applying biotechnology to seed production, winning a string of the sort of patents on living organisms that became legal in America only after a Supreme Court decision in 1980. In July it gave its GM seed a new master brand: Genuity, a name that evokes “being genuine, authentic and original”, according to a company spokesman. It will denote a “family of innovative products that will enable farmers to do what they do best, even better.”

In the 13 years since GM seed was first farmed commercially, agriculture—and Monsanto with it—has become increasingly central to several of the world’s most pressing policy debates, says Mr Grant, a Scot who joined the company in 1981. Nowadays he spends a good deal of his time taking part in those debates, which range from concerns about higher prices and shortages of supply to the use of land for growing biofuels rather than food, climate change and water. Arguments over water, thinks Mr Grant, “will dwarf the discussion that has taken place so far over food.” Monsanto is also getting caught up in the debate over intellectual-property rights in food and their implications for antitrust policy, on which Barack Obama’s administration sounds less friendly than that of George Bush. It has already marked agriculture for attention. How successful Monsanto and rival makers of GM seed, such as DuPont and Syngenta, are in winning round a sceptical public and policymakers will play a big part in determining how lucrative their innovations prove to be. In public attitudes to GM food, Mr Grant believes “there’s been progress everywhere compared with 15 years ago.” Still, Europe remains “slow, a real slouch. European farmers have been denied the right to choose.” Although the European Union is slowly becoming open to imports of GM food, it is still largely opposed to growing the stuff. Monsanto has still to complete a test of any GM seed in Britain because protesters have destroyed its experiments. In Latin America, by contrast, Argentina and Brazil are both growing GM corn (maize) and soyabeans. In some ways, rising awareness of the food crisis has helped people to see “GM as something with potential benefits other than just boosting the profits of Big Food,” says Mr Grant—to Monsanto’s benefit. Well, maybe.

Turbo-charging Mendel
Monsanto’s innovations fall into two categories. The first is breeding, which seedmakers have been doing with increasing sophistication for decades. Monsanto is able to accelerate the process of selective breeding through better mapping of a seed’s genetic qualities and its suitability to grow in a particular place. At Monsanto’s research laboratory in St Louis, the company’s home city, farmers on one of the many tours that are part of its marketing efforts are clearly fascinated by a piece of technology known as the corn chipper. A machine picks up an individual seed, rotates it to the right position, then chips off a sample, which has its genetic material analysed. (Getting the seed in the right position is the hardest step, because each one has a different shape and it is crucial that the chipper does not damage the embryo and thus stop the seed from growing properly.) The likely attributes of the plant that would grow from each seed are predicted from its DNA, the most promising seeds are planted, and the process is repeated with the seeds that those plants go on to produce. The tour guide refers to the operation as “CSI: St Louis”, although testing now goes on all year, at centres around the world. In the past three years this technology has helped speed up dramatically Monsanto’s ability to identify and grow the most productive seed for any given location. “It is the mother and father of all dating agencies: we can analyse every single seed we harvest, do a health check, guess what its grandchildren will be like, send it anywhere in the world,” says Mr Grant. The second category of innovation, in which Monsanto is becoming increasingly adventurous, is genetic modification: identifying genetic traits with particular qualities and transplanting those traits into seeds to improve their performance. In essence, the goal is to pack as much technology into a seed as possible.

The biggest breakthroughs so far have been in weed and bug control. Perhaps the most common feature of Monsanto’s range of seeds is that they are Roundup Ready, meaning that they are guaranteed to survive spraying with Roundup that will take out any surrounding weeds. Some plants have been bioengineered to deter pests from eating their leaves and roots, which reduces or even eliminates the need for insecticides. Farmers on their tours cannot fail to miss the display cases in which a healthy Monsanto plant grows next to a seriously ailing traditional specimen of the same variety. Monsanto has just launched two new varieties of seed that have been engineered to be far more productive: Genuity SmartStax corn, which company trials suggest can increase yields by 5-10%; and Genuity Roundup Ready 2 Yield soyabeans, which in trials have shown yields 7-11% higher than the first generation of Roundup Ready soyabeans. Over the past couple of decades, soyabean yields have risen at an annual rate of barely 1%. In around 2012 or 2013 Monsanto expects to launch a soyabean whose processing will result in fewer transfats. It will also offer an “omega-3 soyabean”, genetically enhanced to give consumers the many proven health benefits of omega-3 fatty acids. Until now, omega-3 has been harvested from fish and so, in Mr Grant’s words, “products with omega-3 in them taste a bit fishy.” Fish derive omega-3 from algae, so Monsanto has done likewise, extracting the relevant genetic material from the algae and putting it into soyabeans. Now, he says, without the fishy taste, omega-3 will go well in yogurts, health bars and so forth.

The company is also aiming to engineer seed to use nitrogen more efficiently—and hence to require less fertiliser. This would reduce farmers’ exposure to the price of oil, from which fertilisers are made, and the damage done when nitrogen leaches into the water supply. In about three years’ time Monsanto expects to launch its first “drought tolerant” products. It is examining several ways of making plants more tolerant of drought. One is to improve the roots’ take-up of water. Another is to reduce water loss through the leaves. A third is to alter plants’ reaction to lack of water. When stressed, a plant shuts down growth in order to conserve what it has. They often over-react, and use a lot of energy when they restart. Genetic modification can help it interpret water conditions more accurately and avoid unnecessary stops and starts. Because water shortages are predicted for many parts of the world, Monsanto expects these drought-tolerant plants to be a huge commercial success. The first of them will be corn, intended for a dry strip of America running from northern Texas to the Dakotas. Drought-tolerant technology has also prompted Monsanto to start focusing on dry-land wheat. Wheat acres have declined in recent years, contributing to shortages. In July the company paid $45m for WestBred, a wheat-seed firm.

Trust and antitrust
Acquisitions have been a key part of Monsanto’s strategy, giving it access to new seed markets. In 2005, it began to apply biotech to vegetables after buying Seminis, the world’s largest vegetable-seed company, for $1.4 billion. Since it was spun off, Monsanto has made more than 20 acquisitions (as well as several disposals). Those purchases are one reason why it was singled out as an appropriate target for the antitrust authorities in a paper published in October by the American Antitrust Institute, an independent competition watchdog. The paper laments the “impaired state of competition in transgenic seed”—which it blames on Monsanto above all. The company’s acquisitions have been crucial in creating the horizontal and vertical integration that support its platforms in cotton, corn and soyabeans. Last year its share of the markets for GM corn and soyabeans was about 65% and that for GM cotton about 45%. The institute’s paper argues that, thanks to its dominance, Monsanto is actually harming innovation in seed. Monsanto had to make concessions to win the antitrust authorities’ approval for two of its biggest purchases, of DeKalb in 1998 and of Delta and Pine Land in 2007. The next generation in the greenhouse True, for the past 13 years Monsanto has been licensing its technology broadly, to hundreds of firms, including some of its main competitors. This, the paper concedes, has ensured that Monsanto has not ended up in “control of large, totally closed platforms in transgenic seed that could be challenged only by the unlikely emergence of rival platforms.” However, it cites Monsanto’s reputation for defending its intellectual property fiercely through the courts as another reason why the antitrust authorities should take a look at the firm.

Monsanto’s terms of business require farmers to buy fresh seed every year. Its new Violator Exclusion Policy denies farmers who break the terms of its licences access to all its technology for ever. This summer it achieved its latest success in enforcing its stern line when it won a case against some Canadian farmers who had held on to seed. Agricultural markets have been mentioned as an area under review by officials in the antitrust division of the Department of Justice. The DoJ is expected to make Google its main target, but it will be no surprise if Monsanto comes a close second. Already, the DoJ is looking into complaints by DuPont, perhaps Monsanto’s fiercest rival. In May Monsanto sued DuPont, alleging that Pioneer, DuPont’s seed arm, had broken licensing terms for herbicide-resistant technology in corn and soyabeans. After an ugly war of words, DuPont countersued and complained to the DoJ. “We are in a hyper-competitive business. Farmers have no shortage of choice,” insists the unapologetic Mr Grant. “Our goal is to be competitive every spring at the farmer’s table. A farmer may be willing to abdicate the decision on what chemicals to use, but not on what seed to plant. We aim to win one field at a time, one spring at a time.” Enforcing licences is crucial to that strategy. Just as in the drug industry, innovation is expensive: Monsanto has a research and development budget of nearly $1 billion a year, and reckons it costs $100m to bring a new GM seed to market. If there is to be innovation, the firm insists, intellectual property must be protected. However, Monsanto is using different language—and a different approach from that of big drugmakers — when it comes to dealing with the millions of poor people in Africa. Mr Grant says that he is determined not to repeat the mistakes of the pharmaceutical industry in holding back on making valuable innovations available to the developing world. He believes that “in a perfect world, on the same day you launch [a drought-resistant seed] in Kansas, you would launch it similarly in Nairobi”—although in practice Africa and other poor places that are short of water will have to wait a while longer.

Over the past three years, the firm has started to play a leading role in efforts collectively described as an attempt to create a “green revolution in Africa”. Mr Grant talks enthusiastically about his friendship with Norman Borlaug, the driving force behind the Green Revolution, first in Mexico, then in Asia, in the second half of the past century, which is generally reckoned to have saved at least 1 billion lives. Shortly before his death this year, aged 95, Borlaug reportedly expressed regret that he would not live to see the “gene revolution”. In white corn, a staple in Africa and Mexico, Monsanto has donated all its intellectual property, seed and know-how for developing drought-tolerant genes to Water Efficient Maize for Africa (WEMA), a public-private partnership that has received grants from the Bill & Melinda Gates Foundation and the foundation of Howard Buffett, an Illinois farmer (and son of Warren Buffett). The five countries to benefit are Kenya, Mozambique, South Africa, Tanzania and Uganda. Mr Grant expects to launch drought-tolerant corn in Africa within two or three years of the launch in America. The company is also working with Millennium Villages, an anti-poverty project led by Jeffrey Sachs, an economist at Columbia University.

Big Pharma versus Big Farma
In contrast to the anti-retroviral drugs that pharmaceutical companies sell in Africa, this product will generate no royalties for Monsanto, says Mr Grant. “The buzzword is the ‘democratisation of technology’ and we have learnt from Big Pharma the dangers of being too slow,” says Mr Grant. The fact that seeds suited to one place do not necessarily grow well elsewhere greatly reduces the risk of parallel imports that affected the drugmakers. They feared that drugs given away in Africa would be shipped back to rich countries, undermining their business there. That said, he does not believe that Monsanto could or should be expected to solve this problem on its own. “We studied what Borlaug did, which was work with local NGOs, tapped research institutes, brought disparate groups together. The new piece today is getting big companies involved, which hopefully means we can get this done much faster than Borlaug did.” Mr Grant nonetheless regards this approach as “good business”, not least because the developing world will be a huge source of future growth for the firm. Monsanto sells more GM cotton in India than in America. Already, most of the countries where GM seed is sown are emerging ones. Around 90% of the world’s 12m farmers with at least a hectare planted with GM seed are smallholders in developing countries. America has 250,000-300,000 active farmers; India has 15m cotton farmers alone, several million of whom Monsanto says it has reached already. This reinforces the firm’s fundamental message, that it is a driving force for higher farm productivity—and that higher productivity, not a return to the methods of the past, is likely to be the true source of agricultural sustainability. In America, GM seed has already brought about huge increases in productivity, says Mr Grant. He has no time for the “Malthusian thing about running out of food. This is eminently solvable.” He sees huge potential in merely raising yields in the rest of the world to levels already achieved in America thanks to better farming practices, Roundup and improved seed productivity. American farmers average about 160 bushels (of 56lb, or 25.5kg) of corn per acre per year, against 60 in Brazil and 27 in sub-Saharan Africa (22 excluding South Africa). Moreover, even in America there is the potential to double yields again. Already, farmers in Iowa are producing as many as 200 bushels an acre. Mr Grant believes that 300 bushels are achievable by 2030. “We have just scratched the surface,” he says, pointing out that after the first GM crops came on the market in 1996, it took ten years for 1 billion acres to be planted. But the second billion took only another three years. “We are where transistors were in the 1970s.”

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the SMELL of MOONDUST


Above: Apollo 12 astronaut Alan Bean displays a “thermos” for moondust–a.k.a. a Special Environmental Sample Container. [More]

http://science.nasa.gov/headlines/y2006/30jan_smellofmoondust.htm

“I wish I could send you some,” says Apollo 17 astronaut Gene Cernan. Just a thimbleful scooped fresh off the lunar surface. “It’s amazing stuff.”

Feel it—it’s soft like snow, yet strangely abrasive.
Taste it—”not half bad,” according to Apollo 16 astronaut John Young.
Sniff it—”it smells like spent gunpowder,” says Cernan.

How do you sniff moondust? Every Apollo astronaut did it. They couldn’t touch their noses to the lunar surface. But, after every moonwalk (or “EVA”), they would tramp the stuff back inside the lander. Moondust was incredibly clingy, sticking to boots, gloves and other exposed surfaces. No matter how hard they tried to brush their suits before re-entering the cabin, some dust (and sometimes a lot of dust) made its way inside. Once their helmets and gloves were off, the astronauts could feel, smell and even taste the moon.


Above: At the end of a long day on the moon, Apollo 17 astronaut Gene Cernan rests inside the lunar module Challenger. Note the smudges of dust on his longjohns and forehead. Photo credit: Jack Schmitt.

The experience gave Apollo 17 astronaut Jack Schmitt history’s first recorded case of extraterrestrial hay fever. “It’s come on pretty fast,” he radioed Houston with a congested voice. Years later he recalls, “When I took my helmet off after the first EVA, I had a significant reaction to the dust. My turbinates (cartilage plates in the walls of the nasal chambers) became swollen.” Hours later, the sensation faded. “It was there again after the second and third EVAs, but at much lower levels. I think I was developing some immunity to it.” Other astronauts didn’t get the hay fever. Or, at least, “they didn’t admit it,” laughs Schmitt. “Pilots think if they confess their symptoms, they’ll be grounded.” Unlike the other astronauts, Schmitt didn’t have a test pilot background. He was a geologist and readily admitted to sniffles. Schmitt says he has sensitive turbinates: “The petrochemicals in Houston used to drive me crazy, and I have to watch out for cigarette smoke.” That’s why, he believes, other astronauts reacted much less than he did.

But they did react: “It is really a strong smell,” radioed Apollo 16 pilot Charlie Duke. “It has that taste — to me, [of] gunpowder — and the smell of gunpowder, too.” On the next mission, Apollo 17, Gene Cernan remarked, “smells like someone just fired a carbine in here.” Schmitt says, “All of the Apollo astronauts were used to handling guns.” So when they said ‘moondust smells like burnt gunpowder,’ they knew what they were talking about.


Above: Aren’t spacesuits supposed to be white? This one, worn by Apollo 17 astronaut Jack Schmitt, is grayed by moondust. [More]

To be clear, moondust and gunpowder are not the same thing. Modern smokeless gunpowder is a mixture of nitrocellulose (C6H8(NO2)2O5) and nitroglycerin (C3H5N3O9). These are flammable organic molecules “not found in lunar soil,” says Gary Lofgren of the Lunar Sample Laboratory at NASA’s Johnson Space Center. Hold a match to moondust–nothing happens, at least, nothing explosive. What is moondust made of? Almost half is silicon dioxide glass created by meteoroids hitting the moon. These impacts, which have been going on for billions of years, fuse topsoil into glass and shatter the same into tiny pieces. Moondust is also rich in iron, calcium and magnesium bound up in minerals such as olivine and pyroxene. It’s nothing like gunpowder.

So why the smell? No one knows. ISS astronaut Don Pettit, who has never been to the moon but has an interest in space smells, offers one possibility: “Picture yourself in a desert on Earth,” he says. “What do you smell? Nothing, until it rains. The air is suddenly filled with sweet, peaty odors.” Water evaporating from the ground carries molecules to your nose that have been trapped in dry soil for months. Maybe something similar happens on the moon. “The moon is like a 4-billion-year-old desert,” he says. “It’s incredibly dry. When moondust comes in contact with moist air in a lunar module, you get the ‘desert rain’ effect–and some lovely odors.” (For the record, he counts gunpowder as a lovely odor.)


Above: The moon–a 4 billion year old desert. [More]

Gary Lofgren has a related idea: “The gases ‘evaporating’ from the moondust might come from the solar wind.” Unlike Earth, he explains, the moon is exposed to the hot wind of hydrogen, helium and other ions blowing away from the sun. These ions hit the moon’s surface and get caught in the dust. It’s a fragile situation. “The ions are easily dislodged by footsteps or dustbrushes, and they would be evaporated by contact with warm air inside the lunar module. Solar wind ions mingling with the cabin’s atmosphere would produce who-knows-what odors.” Want to smell the solar wind? Go to the moon. Schmitt offers yet another idea: The smell, and his reaction to it, could be a sign that moondust is chemically active. “Consider how moondust is formed,” he says. “Meteoroids hit the moon, reducing rocks to jagged dust. It’s a process of hammering and smashing.” Broken molecules in the dust have “dangling bonds”–unsatisfied electrical connections that need atomic partners.


Above: Moondust is formed by pounding; the “hammers” are meteoroids. Image credit: Prof. Larry Taylor, University of Tennessee. [More]

Inhale some moondust and what happens? The dangling bonds seek partners in the membranes of your nose. You get congested. You report strange odors. Later, when the all the bonds are partnered-up, these sensations fade. Another possibility is that moondust “burns” in the lunar lander’s oxygen atmosphere. “Oxygen is very reactive,” notes Lofgren, “and would readily combine with the dangling chemical bonds of the moondust.” The process, called oxidation, is akin to burning. Although it happens too slowly for smoke or flames, the oxidation of moondust might produce an aroma like burnt gunpowder. (Note: Burnt and unburnt gunpowder do not smell the same. Apollo astronauts were specific. Moondust smells like burnt gunpowder.) Curiously, back on Earth, moondust has no smell. There are hundreds of pounds of moondust at the Lunar Sample Lab in Houston. There, Lofgren has held dusty moon rocks with his own hands. He’s sniffed the rocks, sniffed the air, sniffed his hands. “It does not smell like gunpowder,” he says. Were the Apollo crews imagining things? No. Lofgren and others have a better explanation: Moondust on Earth has been “pacified.” All of the samples brought back by Apollo astronauts have been in contact with moist, oxygen-rich air. Any smelly chemical reactions (or evaporations) ended long ago. This wasn’t supposed to happen. Astronauts took special “thermos” containers to the moon to hold the samples in vacuum. But the jagged edges of the dust unexpectedly cut the seals of the containers, allowing oxygen and water vapor to sneak in during the 3-day trip back to Earth. No one can say how much the dust was altered by that exposure.

Schmitt believes “we need to study the dust in situ–on the moon.” Only there can we fully discover its properties: Why does it smell? How does it react with landers, rovers and habitats? What surprises await? NASA plans to send people back to the moon in 2018, and they’ll stay much longer than Apollo astronauts did. The next generation will have more time and better tools to tackle the mystery.

{Author: Dr. Tony Phillips | Production Editor: Dr. Tony Phillips | Credit: Science@NASA}

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